ArticleBehavioural brain research2019
Forgetting at biologically realistic levels of neurogenesis in a large-scale hippocampal model.
Article in Behavioural brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Reconciling the neurogenic hypothesis of depression with recent advances in adult hippocampal neurogenesis research in humans.Molecular psychiatry · 2026Review
- The neuroimmune system and cognition.Nature immunology · 2026Review
- NOD2 activation reprograms infiltrating inflammatory monocytes in the Zika virus infected CNS to maintain neural correlates of learning and memory.bioRxiv : the preprint server for biology · 2026Article
- Aberrantly integrated adult-born immature neurons disrupt brain-wide networks during spatial memory processing.Molecular psychiatry · 2026Article
- Article
- Remote spatial memory deficits in mouse models of neuropsychiatric disorders with immature dentate gyrus phenotype.The international journal of neuropsychopharmacology · 2025Article
- Reduced Adult Neurogenesis in Humans Results From a Tradeoff Rather Than Direct Negative Selection.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Neurogenesis-dependent remodeling of hippocampal circuits reduces PTSD-like behaviors in adult mice.Molecular psychiatry · 2024Article
- Assessments of dentate gyrus function: discoveries and debates.Nature reviews. Neuroscience · 2023Review
- Enhanced excitability but mature action potential waveforms at mossy fiber terminals of young, adult-born hippocampal neurons in mice.Communications biology · 2023Article
- Adult neurogenesis acts as a neural regularizer.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Neurogenesis mediated plasticity is associated with reduced neuronal activity in CA1 during context fear memory retrieval.Scientific reports · 2022Article
- Microglia regulation of synaptic plasticity and learning and memory.Neural regeneration research · 2022Review
- Forgetting as a form of adaptive engram cell plasticity.Nature reviews. Neuroscience · 2022Review
- What Is Adult Hippocampal Neurogenesis Good for?Frontiers in neuroscience · 2022Article
- Vangl2, a Core Component of the WNT/PCP Pathway, Regulates Adult Hippocampal Neurogenesis and Age-Related Decline in Cognitive Flexibility.Frontiers in aging neuroscience · 2022Article
- Voluntary Exercise Increases Neurogenesis and Mediates Forgetting of Complex Paired Associates Memories.Neuroscience · 2021Article
- Functional neurogenesis over the years.Behavioural brain research · 2020Review
Corrections and comments
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Authors and funding
4 authors.
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Abstract
Neurogenesis persists throughout life in the dentate gyrus region of the mammalian hippocampus. Computational models have established that the addition of neurons degrades existing memories (i.e., produces forgetting). These predictions are supported by empirical observations in rodents, where post-training increases in neurogenesis also promote forgetting of hippocampus-dependent memories. However, in these computational models which use 10-1,000 neurons to represent the dentate gyrus, forgetting is only observed at rates of new neuron addition that greatly exceed adult neurogenesis rates observed in vivo. In order to address this, here we generated an artificial neural network which incorporated more realistic features of the hippocampus - including increased network size (with up to 20,000 dentate gyrus neurons), sparse activity, and sparse connectivity - features that were not present in earlier models. In addition, we explored how properties of new neurons - their connectivity, excitability, and plasticity - impact forgetting using a pattern categorization task. Our results revealed that neurogenic networks forget previously learned input-output pattern associations. This forgetting predicted a performance enhancement in subsequent conflictual learning, compared to static networks (with no added neurons). These effects were especially sensitive to changes in increased output connectivity and excitability of new neurons. Crucially, forgetting was observed at much lower rates of neurogenesis in larger networks, with the addition of as little as 0.2% of the total DG population sufficient to induce forgetting.
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