Evidence map›Paper›PMID 31472159›Full record

ArticleAmerican journal of ophthalmology2020

Age-dependent Deformation of the Optic Nerve Head and Peripapillary Retina by Horizontal Duction.

Alan Le, Jessica Chen, Michael Lesgart, Bola A Gawargious, Soh Youn Suh, Joseph L Demer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 31 citations in OpenAlex.

  1. Optic Disc and Retinal Strain Due to Vertical Duction.Investigative ophthalmology & visual science · 2026
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  4. Horizontal Gaze Tolerance and Its Effects on Visual Sensitivity in Glaucoma.Investigative ophthalmology & visual science · 2025
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  11. Changes in Optic Nerve Head Blood Flow During Horizontal Ocular Duction.Investigative ophthalmology & visual science · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alan LeDepartment of Ophthalmology, University of California, Los Angeles, Los Angeles, California, USA; Stein Eye Institute, University of California, Los Angeles, Los Angeles, California, USA; Bioengineering Interdepartmental Programs, University of California, Los Angeles, Los Angeles, California, USA.
Jessica ChenComputational and Systems Biology Interdepartmental Program, University of California, Los Angeles, Los Angeles, California, USA.
Michael LesgartDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
Bola A GawargiousDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, USA.
Soh Youn SuhDepartment of Ophthalmology, University of California, Los Angeles, Los Angeles, California, USA; Stein Eye Institute, University of California, Los Angeles, Los Angeles, California, USA.
Joseph L DemerDepartment of Ophthalmology, University of California, Los Angeles, Los Angeles, California, USA; Stein Eye Institute, University of California, Los Angeles, Los Angeles, California, USA; Bioengineering Interdepartmental Programs, University of California, Los Angeles, Los Angeles, California, USA; Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA; David Geffen Medical School, University of California, Los Angeles, Los Angeles, California, USA. Electronic address: jld@jsei.ucla.edu.
University of California, Los Angeles · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xian-Jie Yang · 1985 to 2026
$16.8M
BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERYR01EY008313 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JOSEPH Louis DEMER · 1991 to 2026
$15.0M
NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY008313
6 · The paper itself

Abstract

purposeTo study effects of age and horizontal duction on deformation of the optic nerve head (ONH) and peripapillary retina (PPR), as reflected by displacement of vascular landmarks, to explore the influence of adduction tethering.

designCross-sectional study.

methodsSetting: University. STUDY POPULATION: Single eyes of 20 healthy young adults (average age 23.9 ± 3.9 [SD] years) were compared to 20 older subjects (average age 61.4 ± 9.3 years). Observational Procedure: The disc and PPR were imaged by scanning laser ophthalmoscopy in central gaze and at 35 degrees abduction and adduction.

main outcome measureDeformations of the disc and adjacent PPR were measured by comparing positions of epipapillary and epiretinal blood vessels.

resultsVessels within the ONH of younger subjects shifted temporally during adduction and nasally during abduction. Displacement of the nasal hemi-disc in adduction was greater at 38.5 ± 1.7 μm (standard error of mean) than the temporal half at 4.1 ± 2.1 μm (P < .001). PPR within 1 radius of the disc margin underwent 7.6 ± 1.6 μm average temporal displacement in adduction in young subjects. In abduction, the young temporal hemi-disc shifted 4.4 ± 0.6 μm nasally without significant displacement in the nasal half. Older subjects' ONH showed less temporal shift and less displacement in the PPR within 1 disc radius (P < .0001) in adduction; the nasal hemi-disc shifted 24.5 ± 1.3 μm compared with 4.4 ± 2.1 μm in the temporal half. There were no significant deformations of the disc during abduction by older subjects.

conclusionLarge horizontal duction, particularly adduction, deforms the disc and peripapillary vasculature. This deformation, which is larger in younger than older subjects, may be due to optic nerve tethering in adduction.

Indexed as

AdultAgedAgingCross-Sectional StudiesFemaleHumansMaleMiddle AgedNerve FibersOcular Motility DisordersOphthalmoscopyOptic DiskOptic Nerve DiseasesRetinaRetinal DiseasesRetinal Ganglion Cells

Identifiers

PMID31472159
PMCPMC6911619
OpenAlexW2970138264

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.