ReviewBritish journal of clinical pharmacology2019
A review of the prescribing trend of thiazide-type and thiazide-like diuretics in hypertension: A UK perspective.
Review in British journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Pitfalls in the pharmacotherapy of hypertension.Clinical medicine (London, England) · 2026Review
- Molecular mechanisms of thiazide-like diuretics-mediated inhibition of the human Na-Cl cotransporter.Nature communications · 2025Article
- Thiazide-Associated Hyponatremia: A Retrospective Cohort Study Comparing Hydrochlorothiazide Versus Indapamide Versus Chlorthalidone.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Prescribing trends and patterns for antihypertensive agents in primary healthcare settings in Qatar: a retrospective observational study.Journal of pharmaceutical policy and practice · 2025Article
- Comparative effectiveness and prescribing trends of modified release versus immediate release indapamide in patients with hypertension: cohort study.BMJ medicine · 2025Article
- Prescription Trends of Thiazide Diuretics in a Canadian Primary Care Population From 2015 to 2021.CJC open · 2024Article
- Article
- Use of Thiazide Diuretics and Risk of All Types of Skin Cancers: An Updated Systematic Review and Meta-Analysis.Cancers · 2022Review
- Perindopril/Indapamide/Amlodipine in Hypertension: A Profile of Its Use.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2022Review
- Association between thiazide diuretics and skin cancer: still nebulous.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2021Article
- Article
- A review of the prescribing trend of thiazide-type and thiazide-like diuretics in hypertension: A UK perspective.British journal of clinical pharmacology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Thiazide diuretics have been the cornerstone of hypertension treatment for >5 decades. Most recent European and American guidelines recommend both thiazide-type and thiazide-like diuretics as first-line drugs for all patients with hypertension. In contrast, diuretics are not regarded as first-line treatment in the UK and in patients who are to be initiated on a diuretic treatment, thiazide-like molecules, such as chlortalidone and indapamide are the preferred option. This review examines the prescribing trend of the 4 most commonly prescribed thiazide diuretics for the treatment of hypertension in the UK. Prescription cost analysis data were obtained for both 2010 and 2016/2017 for each region of the UK to analyse the impact of the 2011 National Institute for Health and Care Excellence hypertension guidelines on the trend in thiazide diuretic prescribing. Overall, the prescriptions of thiazide diuretics declined over the years. Bendroflumethiazide is the most commonly prescribed diuretic in the UK and despite some geographical differences, thiazide-type diuretics are more widely used than thiazide-like. The use of indapamide increased significantly between 2010 and 2016/2017 while chlortalidone was rarely employed. Of the many factors affecting trends in prescriptions, clinical inertia, treatment adherence, availability of the products and the lack of fixed dose combinations may play a role.
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Registered trials
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