Evidence map›Paper›PMID 31471971›Full record

ArticleThe Laryngoscope2020

Retronasal olfactory function in patients with smell loss but subjectively normal flavor perception.

David Tianxiang Liu, Gerold Besser, Bertold Renner, Stefan Seyferth, Thomas Hummel, Christian Albert Mueller

Open access · hybridAbstract read
In one paragraph

Article in The Laryngoscope, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

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  13. Eating behavior in patients with smell loss.Frontiers in nutrition · 2022
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  17. Flavor education and training in olfactory dysfunction: a pilot study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

David Tianxiang LiuDepartment of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-6948-737X
Gerold BesserDepartment of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-3168-7477
Bertold RennerInstitute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Stefan SeyferthDivision of Pharmaceutics, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Thomas HummelSmell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, Dresden, Germany.ORCID 0000-0001-9713-0183
Christian Albert MuellerDepartment of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.
Medical University of Vienna · ATFriedrich-Alexander-Universität Erlangen-Nürnberg · DETaste and Smell Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe human sense of smell constitutes the main part of flavor perception. Typically, patients with loss of olfactory function complain of diminished perception during eating and drinking. However, some patients with smell loss still report normal enjoyment of foods. The aim of the present study was to compare orthonasal and retronasal olfactory function in patients with non-sinonasal smell loss and subjectively normal flavor perception.

methodsNineteen patients (mean age [range] 52.0 [8-83 years]) with self-reported olfactory impairment but subjective normal flavor perception were included. Olfactory performance was assessed using the Sniffin' Sticks (TDI) for orthonasal and the Candy Smell Test (CST) for retronasal function. Visual analogue scales were used for self-assessment of odor (SOP), taste (STP), and flavor perception (SFP), ranging from 0 (no perception) to 10 (excellent perception).

resultsMean (SD) SFP was 8.0 (1.8). Mean (SD) orthonasal TDI-score of all patients was 14.4 (5.3, range 6-25.3) with 11 patients classified as anosmic and eight as hyposmic. Mean/SD retronasal CST-score was 8.8 (2.7, range 3-13) within the range of anosmia/hyposmia. No correlation was found between SFP and the CST (P = .62).

conclusionThe present results showed that despite claiming normal flavor perception, our patients were ortho- and retronasally dysosmic using standard tests for olfactory function. Although other explanations could be possible, we suggest that this subjective flavor perception might be due to unconscious memory recall from previously experienced cross-modal sensory interactions. LEVEL OF EVIDENCE: 4 Laryngoscope, 130:1629-1633, 2020.

Indexed as

SmellTaste PerceptionAdolescentAdultAgedAged, 80 and overChildFemaleFlavoring AgentsHumansMaleMiddle AgedOlfaction DisordersParanasal SinusesTaste DisordersYoung AdultFlavoring Agentsanosmiaflavor perceptionflavor templatesOlfactory dysfunctionretronasal olfactory function

Identifiers

PMID31471971
PMCPMC7318622
OpenAlexW2971320305

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.