Evidence map›Paper›PMID 31471961›Full record

ArticleJournal of medical Internet research2019

Adherence and Satisfaction of Smartphone- and Smartwatch-Based Remote Active Testing and Passive Monitoring in People With Multiple Sclerosis: Nonrandomized Interventional Feasibility Study.

Luciana Midaglia, Patricia Mulero, Xavier Montalban, Jennifer Graves, Stephen L Hauser, Laura Julian, Michael Baker, Jan Schadrack, Christian Gossens, Alf Scotland and 5 more

Erratum issued Registry-linked trialAbstract read
In one paragraph

Article in Journal of medical Internet research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT02952911 (Monitoring of Multiple Sclerosis), which is not on this map. Cited by 82 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02952911 nacompletednot on this map

Monitoring of Multiple Sclerosis (MS) Participants With the Use of Digital Technology (Smartphones and Smartwatches) - A Feasibility Study

TypeinterventionalSponsorHoffmann-La RocheRan2016 to 2018Enrolled100ConditionsMultiple SclerosisArmsSmartphone and Smartwatch
3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. A smartphone sensor-based digital outcome assessment of multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2022
    Trial
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Assessing verbal and spatial memory via smartphone.Frontiers in digital health · 2026
    Article
  12. Article
  13. Article
  14. Sensors in Multiple Sclerosis.Current neurology and neuroscience reports · 2025
    Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Luciana MidagliaDepartment of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia, Vall d'Hebron University Hospital, Barcelona, Spain.ORCID 0000-0001-7981-2228
Patricia MuleroDepartment of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia, Vall d'Hebron University Hospital, Barcelona, Spain.ORCID 0000-0001-8716-8997
Xavier MontalbanDepartment of Neurology-Neuroimmunology, Multiple Sclerosis Centre of Catalonia, Vall d'Hebron University Hospital, Barcelona, Spain.ORCID 0000-0002-0098-9918
Jennifer GravesDepartment of Neurology, University of California, San Diego, San Diego, CA, United States.ORCID 0000-0003-1539-1940
Stephen L HauserDepartment of Neurology, University of California, San Francisco, San Francisco, CA, United States.ORCID 0000-0002-4932-4001
Laura JulianGenentech Inc, South San Francisco, CA, United States.ORCID 0000-0001-5699-302X
Michael BakerF Hoffmann-La Roche Ltd, Basel, Switzerland.ORCID 0000-0002-6854-0375
Jan SchadrackF Hoffmann-La Roche Ltd, Basel, Switzerland.ORCID 0000-0002-2455-5604
Christian GossensF Hoffmann-La Roche Ltd, Basel, Switzerland.ORCID 0000-0003-2660-5895
Alf ScotlandF Hoffmann-La Roche Ltd, Basel, Switzerland.ORCID 0000-0001-9590-8617
Florian LipsmeierF Hoffmann-La Roche Ltd, Basel, Switzerland.ORCID 0000-0002-8663-819X
Johan van BeekF Hoffmann-La Roche Ltd, Basel, Switzerland.ORCID 0000-0002-5641-0004
Corrado BernasconiF Hoffmann-La Roche Ltd, Basel, Switzerland.ORCID 0000-0002-1019-5468
Shibeshih BelachewF Hoffmann-La Roche Ltd, Basel, Switzerland.ORCID 0000-0003-3976-1950
Michael LindemannF Hoffmann-La Roche Ltd, Basel, Switzerland.ORCID 0000-0003-1010-3890

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrent clinical assessments of people with multiple sclerosis are episodic and may miss critical features of functional fluctuations between visits.

objectiveThe goal of the research was to assess the feasibility of remote active testing and passive monitoring using smartphones and smartwatch technology in people with multiple sclerosis with respect to adherence and satisfaction with the FLOODLIGHT test battery.

methodsPeople with multiple sclerosis (aged 20 to 57 years; Expanded Disability Status Scale 0-5.5; n=76) and healthy controls (n=25) performed the FLOODLIGHT test battery, comprising active tests (daily, weekly, every two weeks, or on demand) and passive monitoring (sensor-based gait and mobility) for 24 weeks using a smartphone and smartwatch. The primary analysis assessed adherence (proportion of weeks with at least 3 days of completed testing and 4 hours per day passive monitoring) and questionnaire-based satisfaction. In-clinic assessments (clinical and magnetic resonance imaging) were performed.

resultsPeople with multiple sclerosis showed 70% (16.68/24 weeks) adherence to active tests and 79% (18.89/24 weeks) to passive monitoring; satisfaction score was on average 73.7 out of 100. Neither adherence nor satisfaction was associated with specific population characteristics. Test-battery assessments had an at least acceptable impact on daily activities in over 80% (61/72) of people with multiple sclerosis.

conclusionsPeople with multiple sclerosis were engaged and satisfied with the FLOODLIGHT test battery. FLOODLIGHT sensor-based measures may enable continuous assessment of multiple sclerosis disease in clinical trials and real-world settings.

trial registrationClinicalTrials.gov: NCT02952911; https://clinicaltrials.gov/ct2/show/NCT02952911.

Indexed as

AdultFeasibility StudiesFemaleHumansMaleMiddle AgedMobile ApplicationsMultiple SclerosisSmartphoneTreatment Adherence and ComplianceYoung Adultmobile phonemultiple sclerosispatient adherencepatient satisfactionsmartphonewearable electronic devices

Identifiers

PMID31471961
PMCPMC6743265

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.