Evidence map›Paper›PMID 31471824›Full record

ArticleMycopathologia2019

Cold Atmospheric Pressure Plasma Jet Reduces Trichophyton rubrum Adherence and Infection Capacity.

Aline Chiodi Borges, Thalita Mayumi Castaldelli Nishime, Sabrina de Moura Rovetta, Gabriela de Morais Gouvêa Lima, Konstantin Georgiev Kostov, Gilmar Patrocínio Thim, Beatriz Rossi Canuto de Menezes, João Paulo Barros Machado, Cristiane Yumi Koga-Ito

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In one paragraph

Article in Mycopathologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Aline Chiodi BorgesDepartment of Environmental Engineering and Oral Biopathology Graduate Program, Institute of Science and Technology, São Paulo State University (UNESP), Avenida Engenheiro Francisco José Longo, 777, São José dos Campos, SP, 12245-000, Brazil.ORCID http://orcid.org/0000-0002-6097-9914
Thalita Mayumi Castaldelli NishimeDepartment of Chemistry and Physics, Guaratinguetá Faculty of Engineering, São Paulo State University (UNESP), Av. Dr. Ariberto Pereira da Cunha, 333, Guaratinguetá, SP, 12516-410, Brazil.
Sabrina de Moura RovettaDepartament of Pharmacy, Taubaté Institute of Higher Education (ITES), Avenida Dom Pedro I, 3575, Taubaté, SP, 12090-000, Brazil.
Gabriela de Morais Gouvêa LimaDepartament of Pharmacy, Taubaté Institute of Higher Education (ITES), Avenida Dom Pedro I, 3575, Taubaté, SP, 12090-000, Brazil.
Konstantin Georgiev KostovDepartment of Chemistry and Physics, Guaratinguetá Faculty of Engineering, São Paulo State University (UNESP), Av. Dr. Ariberto Pereira da Cunha, 333, Guaratinguetá, SP, 12516-410, Brazil.
Gilmar Patrocínio ThimDivision of Fundamental Sciences, Instituto Tecnológico de Aeronáutica (ITA), Praça Marechal Eduardo Gomes, 50, São José dos Campos, SP, 12228-970, Brazil.
Beatriz Rossi Canuto de MenezesDivision of Fundamental Sciences, Instituto Tecnológico de Aeronáutica (ITA), Praça Marechal Eduardo Gomes, 50, São José dos Campos, SP, 12228-970, Brazil.
João Paulo Barros MachadoAssociated Laboratory for Sensors and Materials, National Institute for Space Research, Avenida dos Astronautas, 1758, São José dos Campos, SP, 12227-010, Brazil.
Cristiane Yumi Koga-ItoDepartament of Pharmacy, Taubaté Institute of Higher Education (ITES), Avenida Dom Pedro I, 3575, Taubaté, SP, 12090-000, Brazil. cristiane@ict.unesp.br.
Universidade de Taubaté · BRInstituto Tecnológico de Aeronáutica · BRInstituto Nacional de Pesquisas Espaciais · BRLeibniz Institute for Plasma Science and Technology · DEUniversidade Estadual Paulista (Unesp) · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/02354-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/21989-6Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/07196-6
6 · The paper itself

Abstract

This study aimed to evaluate the effects of cold atmospheric pressure plasma (CAPP) jet on Trichophyton rubrum growth, germination and adherence to nail. The effects of plasma jet on T. rubrum conidia germination and on mycelial growth were evaluated by in vitro assays. An ex vivo nail infection model was used to evaluate the effects on conidia adherence and infection. Biochemical analyses of nail fragments exposed or not to CAPP were performed by attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy. Plasma jet exposure for 10 and 15 min completely inhibited mycelial growth after only one exposure. Fifteen minutes of exposure could reduce conidia germination in suspension. Fungal suspensions exposed to plasma jet for 10 and 15 min were not able to infect nail specimens. These results were corroborated by ATR-FTIR analyses of nail fragments. In conclusion, single exposure to CAPP for 15 min was able to inhibit fungal growth, adherence and infection capacity. The results suggest that cold atmospheric plasma jet can be a promising alternative for the treatment of onychomycoses caused by T. rubrum.

Indexed as

Atmospheric PressurePlasma GasesCell AdhesionHealthy VolunteersHumansModels, TheoreticalMyceliumNailsTineaTrichophytonPlasma GasesAntifungal agentsCold plasmaOnychomycosisTrichophyton rubrum

Identifiers

PMID31471824
OpenAlexW2970430670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.