Evidence map›Paper›PMID 31471702›Full record

ArticleMagma (New York, N.Y.)2020

Renal sinus fat and renal hemodynamics: a cross-sectional analysis.

Karlinde A Spit, Marcel H A Muskiet, Lennart Tonneijck, Mark M Smits, Mark H H Kramer, Jaap A Joles, Anneloes de Boer, Daniel H van Raalte

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magma (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Visceral Adiposity and Progression of ADPKD: A Cohort Study of Patients From the TEMPO 3:4 Trial.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024
    Trial
  4. Article
  5. Review
  6. Article
  7. Rationale, design and baseline characteristics of the TRANSCEND-CKD trial of retatrutide in patients with chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Karlinde A SpitDepartment of Internal Medicine, Diabetes Center, Amsterdam University Medical Centers, Location VUMC, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Marcel H A MuskietDepartment of Internal Medicine, Diabetes Center, Amsterdam University Medical Centers, Location VUMC, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Lennart TonneijckDepartment of Internal Medicine, Diabetes Center, Amsterdam University Medical Centers, Location VUMC, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Mark M SmitsDepartment of Internal Medicine, Diabetes Center, Amsterdam University Medical Centers, Location VUMC, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Mark H H KramerDepartment of Internal Medicine, Diabetes Center, Amsterdam University Medical Centers, Location VUMC, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Jaap A JolesDepartment of Nephrology and Hypertension, University Medical Center, Utrecht, The Netherlands.
Anneloes de BoerDepartment of Radiology, University Medical Center, Utrecht, The Netherlands.
Daniel H van RaalteDepartment of Internal Medicine, Diabetes Center, Amsterdam University Medical Centers, Location VUMC, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands. d.vanraalte@vumc.nl.ORCID http://orcid.org/0000-0003-2894-6124
Amsterdam University Medical Centers · NLUniversity Medical Center Utrecht · NL

Funding

Horizon 2020 under grant agreement 282521, the SAFEGUARD projectNierstichting under grant agreement IP12.87
6 · The paper itself

Abstract

objectivesIncreased renal sinus fat (RSF) is associated with hypertension and chronic kidney disease, but underlying mechanisms are incompletely understood. We evaluated relations between RSF and gold-standard measures of renal hemodynamics in type 2 diabetes (T2D) patients.

methodsFifty-one T2D patients [age 63 ± 7 years; BMI 31 (28-34) kg/m

resultsRSF correlated negatively with GFR (r = - 0.38; p = 0.006) and ERPF (r = - 0.38; p = 0.006) and positively with mean arterial pressure (MAP) (r = 0.29; p = 0.039) and ERVR (r = 0.45, p = 0.001), which persisted after adjustment for VAT, MAP, sex, and BMI. After correction for age, ERVR remained significantly related to RSF.

conclusionsIn T2D patients, higher RSF volume was negatively associated to GFR. In addition, RSF volume was positively associated with increased renal vascular resistance, which may mediate hypertension and CKD development. Further research is needed to investigate how RSF may alter the (afferent) vascular resistance of the renal vasculature.

Indexed as

HemodynamicsAdultAgedBody Mass IndexCross-Sectional StudiesDiabetes Mellitus, Type 2FemaleHumansHypertensionInulinKidneyKidney Failure, ChronicMagnetic Resonance ImagingMaleMiddle AgedInulinDiabetic kidney diseaseHypertensionRenal hemodynamicsRenal sinus fatType 2 diabetes

Identifiers

PMID31471702
PMCPMC7021744
OpenAlexW2971051718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.