Evidence map›Paper›PMID 31471697›Full record

ArticleInternational journal of colorectal disease2019

Familial and non-familial risk factors associated with colorectal cancer survival in young and middle-aged patients.

Erin Kelty, Sarah V Ward, Gemma Cadby, Nina S McCarthy, Peter O'Leary, Eric K Moses, Hooi C Ee, David B Preen

Abstract read
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In one paragraph

Article in International journal of colorectal disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Erin KeltySchool of Population and Global Health, The University of Western Australia, Crawley, WA, 6009, Australia. erin.kelty@uwa.edu.au.ORCID http://orcid.org/0000-0002-0841-2216
Sarah V WardCentre for Genetic Origins of Health and Disease, School of Biomedical Sciences, the University of Western Australia, Crawley, WA, 6009, Australia.
Gemma CadbyCentre for Genetic Origins of Health and Disease, School of Biomedical Sciences, the University of Western Australia, Crawley, WA, 6009, Australia.
Nina S McCarthyCentre for Genetic Origins of Health and Disease, School of Biomedical Sciences, the University of Western Australia, Crawley, WA, 6009, Australia.
Peter O'LearySchool of Pharmacy and Biomedical Sciences, Curtin University, Bentley, WA, 6102, Australia.
Eric K MosesCentre for Genetic Origins of Health and Disease, School of Biomedical Sciences, the University of Western Australia, Crawley, WA, 6009, Australia.
Hooi C EeDepartment of Gastroenterology, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia.
David B PreenSchool of Population and Global Health, The University of Western Australia, Crawley, WA, 6009, Australia.
The University of Western Australia · AUMemorial Sloan Kettering Cancer Center · USSir Charles Gairdner Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSurvival following colorectal cancer (CRC) survival may be influenced by a number of factors including family history, individual medical history, and comorbidities. The impact of these factors may vary based on the patient's age.

methodsThe study cohort consisted of individuals born in Western Australia between 1945 and 1996, who had been diagnosed with CRC prior to 2015 (n = 3220). Hospital, cancer, and mortality data were extracted for each patient from state health records and were used to identify potential risk factors associated with CRC survival. Family linkage data, in combination with cancer registry data, were used to identify first-degree family members with a history of CRC. The association between survival following CRC diagnosis and identified risk factors was examined using Cox proportional hazard models.

resultsAge and sex were not significantly associated with survival in young patients. However, in middle-aged patients increasing age (HR 1.03, 95% CI 1.01-1.05, p = 0.003) and being male (HR 0.72, 95% CI 0.60-0.87, p < 0.001) were associated with reduced survival. Being diagnosed with polyps and having a colonoscopy prior to CRC diagnosis were associated with improved survival in both young and middle-aged patients, while a history of non-CRC and liver disease was associated with reduced survival. In middle-aged patients, having diabetes-related hospital admissions (HR 1.53, 95% CI 1.15-2.03, p = 0.004) was associated with reduced survival.

conclusionsIn both young and middle-aged patients with CRC, factors associated with early screening and detection were associated with increased CRC survival while a history of liver disease and non-CRC was associated with decreased CRC survival.

Indexed as

AdolescentAdultAgedColorectal NeoplasmsFemaleHumansMaleMiddle AgedMultivariate AnalysisRisk FactorsSurvival AnalysisYoung AdultColorectal cancerFamily historyMiddle-agedRisk factorsSurvivalYoung

Identifiers

PMID31471697
OpenAlexW2971061969

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.