ArticlePlanta2019
Whole-genome DNA methylation patterns and complex associations with gene expression associated with anthocyanin biosynthesis in apple fruit skin.
Article in Planta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 69 citations in OpenAlex.
- Molecular Mechanisms and Regulation of Anthocyanin Biosynthesis in Rosaceae Fruits: A Review.Food science & nutrition · 2026Review
- Regulatory insights underlying apple to cold stress.Horticulture research · 2026Article
- Integrated Analysis of DNA Methylation and Transcriptomic Dynamics in the Grape Variety 'Cabernet Franc' at Early and Late Stages of Fruit Development.Plants (Basel, Switzerland) · 2026Article
- Subfunctionalization and epigenetic regulation of a biosynthetic gene cluster inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multi-omics analysis reveals key regulatory defense pathways and genes involved in salt tolerance of rose plants.Horticulture research · 2024Article
- Hypermethylation in the promoter regions of flavonoid pathway genes is associated with skin color fading during 'Daihong' apple fruit development.Horticulture research · 2024Article
- A high-density linkage map construction in guava (Frontiers in plant science · 2024Article
- Multilayered regulation of secondary metabolism in medicinal plants.Molecular horticulture · 2023Review
- Insights on the stem elongation of spur-type bud sport mutant of 'Red Delicious' apple.Planta · 2023Article
- Developmental dynamic transcriptome and systematic analysis reveal the major genes underlying isoflavone accumulation in soybean.Frontiers in plant science · 2023Article
- Identification of Candidate Genes Associated with Pulp Color by Transcriptomic Analysis of 'Huaxiu' Plum (Current issues in molecular biology · 2022Article
- Integrative analysis of transcriptome and metabolome reveals the effect of DNA methylation of chalcone isomerase gene in promoter region onSynthetic and systems biotechnology · 2022Article
- Zebularine, a DNA Methylation Inhibitor, Activates Anthocyanin Accumulation in Grapevine Cells.Genes · 2022Article
- A Survey of Enhanced Cold Tolerance and Low-Temperature-Induced Anthocyanin Accumulation in a NovelPlants (Basel, Switzerland) · 2022Article
- Systematic genome-wide and expression analysis of RNA-directed DNA methylation pathway genes in grapes predicts their involvement in multiple biological processes.Frontiers in plant science · 2022Article
- Research Progress on Genetic Basis of Fruit Quality Traits in Apple (Frontiers in plant science · 2022Review
- Multilevel regulation of anthocyanin-promoting R2R3-MYB transcription factors in plants.Frontiers in plant science · 2022Review
- Involvement of histone deacetylase CsHDA2 in regulating (Horticulture research · 2022Article
- Feasible strategies for studying the involvement of DNA methylation and histone acetylation in the stress-induced formation of quality-related metabolites in tea (Camellia sinensis).Horticulture research · 2021Review
- Combined Profiling of Transcriptome and DNA Methylome Reveal Genes Involved in Accumulation of Soluble Sugars and Organic Acid in Apple Fruits.Foods (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
MAIN
conclusionDNA methylation of anthocyanin biosynthesis-related genes and MYB/bHLH transcription factors was associated with apple fruit skin color revealed by whole-genome bisulfite sequencing. DNA methylation is a common feature of epigenetic regulation and is associated with various biological processes. Anthocyanins are among the secondary metabolites that contribute to fruit colour, which is a key appearance and nutrition quality attribute of apple fruit. Although few studies reported that DNA methylation in the promoter of MYB transcription factor was associated with fruit skin color, there is a general lack of understanding of the dynamics of global and genic DNA methylation in apple fruit. Here, whole-genome bisulfite sequencing was carried out in fruit skin of apple (Malus domestica Borkh.) cv. 'Red Delicious' (G0) and its four-generation bud sport mutants, including 'Starking Red' (G1), 'Starkrimson' (G2), 'Campbell Redchief' (G3) and 'Vallee spur' (G4) at color break stage. Correlation and linear-regression analysis between DNA methylation level and anthocyanin content, as well as the transcription levels of genes related to anthocyanin biosynthesis were carried out. The results showed that the number of differentially methylated regions (DMRs) and differentially methylated genes (DMGs) was considerably increased from G1 to G4 versus the number observed in G0. The
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