Evidence map›Paper›PMID 31471531›Full record

ArticleBioscience reports2019

EBV encoded miRNA BART8-3p promotes radioresistance in nasopharyngeal carcinoma by regulating ATM/ATR signaling pathway.

Xiaohan Zhou, Jialing Zheng, Ying Tang, Yanling Lin, Lingzhi Wang, Ye Li, Chengdong Liu, Dehua Wu, Longmei Cai

Expression of concernOpen access · goldAbstract read
In one paragraph

Article in Bioscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It carries an expression of concern. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiaohan ZhouDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0001-7780-5593
Jialing ZhengDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ying TangDepartment of Obstetrics and Gynaecology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Yanling LinDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Lingzhi WangDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ye LiDepartment of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0002-0255-3915
Chengdong LiuDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Dehua WuDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China wudehua.gd@gmail.com cailongmeibestlove@163.com.
Longmei CaiDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China wudehua.gd@gmail.com cailongmeibestlove@163.com.ORCID 0000-0003-0421-464X
Nanfang Hospital · CNZhujiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resistance to radiotherapy is one of the main causes of treatment failure in patients with nasopharyngeal carcinoma (NPC). Epstein-Barr virus (EBV) infection is an important factor in the pathogenesis of NPC, and EBV-encoded microRNAs (miRNAs) promote NPC progression. However, the role of EBV-encoded miRNAs in the radiosensitivity of NPC remains unclear. Here, we investigated the effects of EBV-miR-BART8-3p on radiotherapy resistance in NPC cells

Indexed as

AnimalsApoptosisAtaxia Telangiectasia Mutated ProteinsCell ProliferationDNA RepairHerpesvirus 4, HumanHumansIndolesMaleMiceMice, NudeMicroRNAsMorpholinesNasopharyngeal CarcinomaNasopharyngeal NeoplasmsPyrimidines2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamideAtaxia Telangiectasia Mutated ProteinsATM protein, humanATR protein, humanceralasertibIndolesMicroRNAsMorpholinesPyrimidinesSulfonamidesSulfoxidesThioxanthenesATM/ATRDSBsEBV-miR-BART8-3pNPCradioresistance

Identifiers

PMID31471531
PMCPMC6744588
OpenAlexW2970778323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.