Trial reportJournal of neurointerventional surgery2020
First pass effect with contact aspiration and stent retrievers in the Aspiration versus Stent Retriever (ASTER) trial.
Trial report in Journal of neurointerventional surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02523261 (Interest of Direct Aspiration First Pass Technique), which is not on this map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interest of Direct Aspiration First Pass Technique (ADAPT) for Thrombectomy Revascularisation of Large Vessel Occlusion in Acute Ischaemic Stroke
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review and meta-analysis of current rates of first pass effect by thrombectomy technique and associations with clinical outcomes.Journal of neurointerventional surgery · 2021Pooled it
- Factors Influencing Recanalization After Mechanical Thrombectomy With First-Pass Effect for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2021Pooled it
- Effect of Intravenous Tirofiban Versus Placebo on First-Pass Successful Reperfusion in Endovascular Stroke Thrombectomy: Insights From the RESCUE BT Randomized Clinical Trial.Journal of the American Heart Association · 2024Trial
- Sex-Based Efficacy of Endovascular Thrombectomy Techniques in LVO Stroke: A Multicenter Registry Analysis.Stroke · 2026Article
- Impact of neutrophil extracellular traps on the mechanical, radiomic, and histological properties of in vitro stroke clots.Acta neurologica Belgica · 2026Article
- Unfavorable clinical outcomes in patients with good collateral scores following endovascular treatment for acute ischemic stroke of the anterior circulation: The UNCLOSE study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- First-line Aspiration Thrombectomy with the RED43 Catheter for Acute Ischemic Stroke due to Medium or Distal Vessel Occlusion.Clinical neuroradiology · 2026Article
- Is Personalized Mechanical Thrombectomy Based on Clot Characteristics Feasible? A Radiomics Model Using NCECT to Predict FPE in AIS Patients Undergoing Thromboaspiration.Journal of clinical medicine · 2025Article
- Stent retriever versus aspiration based thrombectomy: impact on first pass reperfusion, procedure time, and clinical outcomes in large vessel occlusion. Nationwide registry based cohort study.Journal of neurointerventional surgery · 2025Article
- Overcoming the black box of aspiration thrombectomy in acute ischemic stroke: An early clinical experience of using contrast injections to understand clot-catheter interactions.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Preliminary results of mechanical thrombectomy with the novel Titan aspiration catheter in acute ischemic stroke patients.Neurosurgical review · 2025Article
- The ASCEND Technique-A Modified Direct Aspiration First Pass Technique for a Faster and Cost-effective Mechanical Thrombectomy.Clinical neuroradiology · 2025Article
- Contact Aspiration Combined with a Stent Retriever versus Contact Aspiration Alone in Mechanical Thrombectomy for Acute Ischemic Strokes: A Nationwide Analysis Using the Diagnosis Procedure Combination Database.Journal of neuroendovascular therapy · 2025Article
- Contribution of Large Bore Aspiration Catheter to Mechanical Thrombectomy.Journal of neuroendovascular therapy · 2025Article
- Predictors of outcome and symptomatic intracranial hemorrhage in acute basilar artery occlusions: Analysis of the PC-SEARCH thrombectomy registry.European stroke journal · 2024Article
- A Deep Learning Approach to Predict Recanalization First-Pass Effect following Mechanical Thrombectomy in Patients with Acute Ischemic Stroke.AJNR. American journal of neuroradiology · 2024Article
- Current Approaches and Methods to Understand Acute Ischemic Stroke Treatment Using Aspiration Thrombectomy.Cardiovascular engineering and technology · 2024Review
- Impact of Target Artery Size on the Performance of Aspiration Thrombectomy: Insights from a Swine Model with Real-Time Visualization.AJNR. American journal of neuroradiology · 2024Article
- Initial clinical experience with a novel mechanical thrombectomy device-the ThrombX retriever.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024Article
- A prospective, multicentre, registry study of RECO in the endovascular treatment of acute ischaemic stroke.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe 'first pass effect' (FPE), which was originally described with stent retrievers, designates a (near-)complete revascularization obtained after a single device pass with no rescue therapy, and is associated with improved clinical outcome and decreased mortality.
objectiveWe report the rate and benefits of FPE in the Aspiration versus Stent Retriever (ASTER) trial. MATERIALS AND
methodsASTER is a randomized trial comparing angiographic revascularization with the stent retriever (SR) and contact aspiration (CA) thrombectomy techniques, assessed by an external core laboratory using the modified Thrombolysis in Cerebral Infarction (mTICI) scale. Rates of FPE (defined by mTICI 2c/3 after a single pass with no rescue therapy) were compared between patients treated with SR and CA techniques. Outcomes were compared between FPE-SR and FPE-CA patients, and between FPE and non-FPE patients.
resultsFPE was achieved in 97/336 patients (28.9%), with no significant difference between SR and CA (respectively 53/169 patients (31.3%) vs 44/167 patients (26.3%), adjusted RR for CA versus SR 0.84, 95% CI 0.54 to 1.31; p=0.44). After prespecified adjustment for allocated arm and randomization stratification factors, FPE in patients was associated with a significantly improved clinical outcome and a decreased mortality, and a significantly lower rate of hemorrhagic transformation and procedural complications than in non-FPE patients.
conclusionIn the ASTER trial, similar rates of FPE were achieved with SR and CA, and FPE was associated with a significantly improved outcome. New techniques and devices to improve the rate of FPE are warranted. TRIAL REGISTRATION NUMBER: Unique identifier: NCT02523261.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.