Evidence map›Paper›PMID 31471495›Full record

ArticleMolecular & cellular proteomics : MCP2019

A Robust and Versatile Automated Glycoanalytical Technology for Serum Antibodies and Acute Phase Proteins: Ovarian Cancer Case Study.

Róisín O'Flaherty, Mohankumar Muniyappa, Ian Walsh, Henning Stöckmann, Mark Hilliard, Richard Hutson, Radka Saldova, Pauline M Rudd

Open access · hybridAbstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Age-Related Changes in SerumBiomolecules · 2023
    Article
  7. Article
  8. Article
  9. High-Throughput Glycomic Methods.Chemical reviews · 2022
    Review
  10. Changes in SerumBiomolecules · 2022
    Article
  11. Article
  12. Review
  13. Automation of Immunoglobulin Glycosylation Analysis.Experientia supplementum (2012) · 2021
    Review
  14. Non-Enzymatic Glycation of Transferrin and Diabetes Mellitus.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Róisín O'FlahertyNIBRT GlycoScience Group, National Institute for Bioprocessing Research and Training, Fosters Avenue, Mount Merrion, Blackrock, Dublin 4, Ireland, A94X099.
Mohankumar MuniyappaNIBRT GlycoScience Group, National Institute for Bioprocessing Research and Training, Fosters Avenue, Mount Merrion, Blackrock, Dublin 4, Ireland, A94X099.
Ian WalshBioprocessing Technology Institute, Agency for Science, Technology and Research (ASTAR), 20 Biopolis Way, #06-01 Centros, Singapore 138668, Singapore.
Henning StöckmannNIBRT GlycoScience Group, National Institute for Bioprocessing Research and Training, Fosters Avenue, Mount Merrion, Blackrock, Dublin 4, Ireland, A94X099.
Mark HilliardNIBRT GlycoScience Group, National Institute for Bioprocessing Research and Training, Fosters Avenue, Mount Merrion, Blackrock, Dublin 4, Ireland, A94X099.
Richard HutsonCancer Research UK Clinical Centre at Leeds, St James' University Hospital, Leeds LS9 7TF, UK. Electronic address: roisin.oflaherty@nibrt.ie.
Radka SaldovaNIBRT GlycoScience Group, National Institute for Bioprocessing Research and Training, Fosters Avenue, Mount Merrion, Blackrock, Dublin 4, Ireland, A94X099; UCD School of Medicine, College of Health and Agricultural Science, University College Dublin, Belfield, Dublin 4, Ireland.
Pauline M RuddNIBRT GlycoScience Group, National Institute for Bioprocessing Research and Training, Fosters Avenue, Mount Merrion, Blackrock, Dublin 4, Ireland, A94X099.
National Institute for Bioprocessing Research and Training · IEAgency for Science, Technology and Research · SGCancer Research UK · GBUniversity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The direct association of the genome, transcriptome, metabolome, lipidome and proteome with the serum glycome has revealed systems of interconnected cellular pathways. The exact roles of individual glycoproteomes in the context of disease have yet to be elucidated. In a move toward personalized medicine, it is now becoming critical to understand disease pathogenesis, and the traits, stages, phenotypes and molecular features that accompany it, as the disruption of a whole system. To this end, we have developed an innovative technology on an automated platform, "GlycoSeqCap," which combines

Indexed as

Acute-Phase ProteinsBiomarkers, TumorCase-Control StudiesFemaleGlycomicsGlycoproteinsGlycosylationHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MNeoplasm MetastasisOvarian NeoplasmsPilot ProjectsPolysaccharidesProteomeAcute-Phase ProteinsBiomarkers, TumorGlycoproteinsImmunoglobulin AImmunoglobulin GImmunoglobulin MPolysaccharidesProteomeacute phase proteinsantibodiesglycomicsglycoproteinsglycosylationovarian cancerplasma or serum analysis

Identifiers

PMID31471495
PMCPMC6823853
OpenAlexW2970219824

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.