ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Extensive Inhibitory Gating of Viscerosensory Signals by a Sparse Network of Somatostatin Neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Anatomy and function of efferent and afferent vagal innervation of the stomach.Autonomic neuroscience : basic & clinical · 2026Review
- A brainstem pathway underlying vagal modulation of somatic pain and affective states.Nature neuroscience · 2026Article
- Somatostatin neurons in the rostral nucleus of the solitary tract are functionally heterogeneous.bioRxiv : the preprint server for biology · 2026Article
- Engaging Gut-to-Brain Signalling to Treat Alcohol Use Disorder.Addiction biology · 2026Article
- Cellular coding of ingestion in the caudal brainstem.bioRxiv : the preprint server for biology · 2026Article
- Interoceptive processing in the nucleus of the solitary tract.Current opinion in neurobiology · 2025Review
- A brainstem map for visceral sensations.Nature · 2022Article
- Interactions between Brainstem Neurons That Regulate the Motility to the Stomach.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Brainstem Neuronal Circuitries Controlling Gastric Tonic and Phasic Contractions: A Review.Cellular and molecular neurobiology · 2022Review
- Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception.International journal of molecular sciences · 2022Review
- Brainstem activation of GABAFrontiers in neuroscience · 2022Article
- Target-specific projections of amygdala somatostatin-expressing neurons to the hypothalamus and brainstem.Chemical senses · 2022Article
- The Organization of Somatostatin-Immunoreactive Cells in the Visual Cortex of the Gerbil.Biomedicines · 2022Article
- Depleting hypothalamic somatostatinergic neurons recapitulates diabetic phenotypes in mouse brain, bone marrow, adipose and retina.Diabetologia · 2021Article
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Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Integration and modulation of primary afferent sensory information begins at the first terminating sites within the CNS, where central inhibitory circuits play an integral role. Viscerosensory information is conveyed to the nucleus of the solitary tract (NTS) where it initiates neuroendocrine, behavioral, and autonomic reflex responses that ensure optimal internal organ function. This excitatory input is modulated by diverse, local inhibitory interneurons, whose functions are not clearly understood. Here we show that, in male rats, 65% of somatostatin-expressing (SST) NTS neurons also express GAD67, supporting their likely role as inhibitory interneurons. Using whole-cell recordings of NTS neurons, from horizontal brainstem slices of male and female SST-yellow fluorescent protein (YFP) and SST-channelrhodopsin 2 (ChR2)-YFP mice, we quantified the impact of SST-NTS neurons on viscerosensory processing. Light-evoked excitatory photocurrents were reliably obtained from SST-ChR2-YFP neurons (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.