ArticleNeurology(R) neuroimmunology & neuroinflammation2019
Late-onset neuromyelitis optica spectrum disorder: The importance of autoantibody serostatus.
Open access · goldAbstract readComparative StudyMulticenter Study
In one paragraph
Article in Neurology(R) neuroimmunology & neuroinflammation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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37citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
What it found
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The trial behind it
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Double-Negative Neuromyelitis Optica Spectrum Disorder: A Systematic Review and Meta-Analysis.Neurology(R) neuroimmunology & neuroinflammation · 2026Pooled it
- Sex ratio and age of onset in AQP4 antibody-associated NMOSD: a review and meta-analysis.Journal of neurology · 2024Pooled it
- Optimizing the Use of Anti-CD20 Agents in Multiple Sclerosis and Other Autoimmune Central Nervous System Disorders: A Narrative Review.Neurology and therapy · 2026Review
- Review
- Therapeutic Apheresis for Intravenous Methylprednisolone-Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single-Center Case Series.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026Article
- Myelitis-Predominant Aggressive Phenotype: Unveiling Unique Patterns of Late-Onset Neuromyelitis Optica Spectrum Disorders.Annals of neurology · 2026Article
- Disability and Relapse Risk in Late-Onset Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.JAMA network open · 2026Article
- Clinical Characteristics and Outcomes of Early-Onset Versus Late-Onset LGI1-Antibody Encephalitis.Annals of clinical and translational neurology · 2026Article
- Novel B-Cell targeting therapy with subcutaneous ofatumumab in AQP4-IgG-seronegative Neuromyelitis Optica Spectrum Disorders: efficacy and personalized dosing.Frontiers in immunology · 2026Article
- Severe attacks and worse prognosis in patients with late-onset neuromyelitis optica spectrum disorder highlight the need for early highly effective treatment.Journal of neurology · 2025Article
- Double-negative NMOSD: from case report to a proposed diagnostic and therapeutic algorithm.BMC neurology · 2025Article
- Clinical Features and Factors Associated With Outcome in Late Adult-Onset Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.Neurology · 2025Observational
- Clinical and immunological differences between primary and autoimmune-associated neuromyelitis optica spectrum disorders: a retrospective study.Lupus science & medicine · 2025Article
- Worse recovery from acute attacks and faster disability accumulation highlights the unmet need for improved treatment in patients with late-onset neuromyelitis optica spectrum disorders (COPTER-LO study).Frontiers in immunology · 2025Article
- Clinical features and visual prognosis of very late-onset neuromyelitis optica spectrum disorder-related optic neuritis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Patterns of neuromyelitis optica spectrum disorder attacks in different age groups and sexes depending on the status of immunosuppressive therapy: A retrospective cohort study.European journal of neurology · 2024Article
- The relationship between neuromyelitis optica spectrum disorder and autoimmune diseases.Frontiers in immunology · 2024Article
- Double-negative neuromyelitis optica spectrum disorder.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Review
- Initial BMI effects on clinical presentation and prognosis in neuromyelitis optica spectrum disorder.Annals of clinical and translational neurology · 2023Article
- Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD) - revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part I: Diagnosis and differential diagnosis.Journal of neurology · 2023Review
Corrections and comments
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Authors and funding
16 authors at 1 institution in 3 countries.
Maria SepulvedaFrom the Center of Neuroimmunology (M.S., G.D.-G., Y.B., N.S.-V., E.H.M.-L., T.A., C.M., I.P.-V., E.M.-H., H.A., D.E., S.L., J.D., F.G., A.S.), Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain; Division of Neurology (G.D.-G.), National Institute of Neurology and Neurosurgery, Mexico City; Pediatric Neuroimmunology Unit (T.A.), Neurology Service, Sant Joan de Deu Children's Hospital, University of Barcelona, Spain; Servicio de Inmunología (R.R.-G.), Centro de Diagnóstico Biomédico, Hospital Clinic of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.ORCID 0000-0002-3078-645X
Guillermo Delgado-GarcíaFrom the Center of Neuroimmunology (M.S., G.D.-G., Y.B., N.S.-V., E.H.M.-L., T.A., C.M., I.P.-V., E.M.-H., H.A., D.E., S.L., J.D., F.G., A.S.), Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain; Division of Neurology (G.D.-G.), National Institute of Neurology and Neurosurgery, Mexico City; Pediatric Neuroimmunology Unit (T.A.), Neurology Service, Sant Joan de Deu Children's Hospital, University of Barcelona, Spain; Servicio de Inmunología (R.R.-G.), Centro de Diagnóstico Biomédico, Hospital Clinic of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.ORCID 0000-0002-3123-5879
Yolanda BlancoFrom the Center of Neuroimmunology (M.S., G.D.-G., Y.B., N.S.-V., E.H.M.-L., T.A., C.M., I.P.-V., E.M.-H., H.A., D.E., S.L., J.D., F.G., A.S.), Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain; Division of Neurology (G.D.-G.), National Institute of Neurology and Neurosurgery, Mexico City; Pediatric Neuroimmunology Unit (T.A.), Neurology Service, Sant Joan de Deu Children's Hospital, University of Barcelona, Spain; Servicio de Inmunología (R.R.-G.), Centro de Diagnóstico Biomédico, Hospital Clinic of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.
Nuria Sola-VallsFrom the Center of Neuroimmunology (M.S., G.D.-G., Y.B., N.S.-V., E.H.M.-L., T.A., C.M., I.P.-V., E.M.-H., H.A., D.E., S.L., J.D., F.G., A.S.), Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain; Division of Neurology (G.D.-G.), National Institute of Neurology and Neurosurgery, Mexico City; Pediatric Neuroimmunology Unit (T.A.), Neurology Service, Sant Joan de Deu Children's Hospital, University of Barcelona, Spain; Servicio de Inmunología (R.R.-G.), Centro de Diagnóstico Biomédico, Hospital Clinic of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.
Elena H Martinez-LapiscinaFrom the Center of Neuroimmunology (M.S., G.D.-G., Y.B., N.S.-V., E.H.M.-L., T.A., C.M., I.P.-V., E.M.-H., H.A., D.E., S.L., J.D., F.G., A.S.), Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain; Division of Neurology (G.D.-G.), National Institute of Neurology and Neurosurgery, Mexico City; Pediatric Neuroimmunology Unit (T.A.), Neurology Service, Sant Joan de Deu Children's Hospital, University of Barcelona, Spain; Servicio de Inmunología (R.R.-G.), Centro de Diagnóstico Biomédico, Hospital Clinic of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.
Thaís ArmanguéFrom the Center of Neuroimmunology (M.S., G.D.-G., Y.B., N.S.-V., E.H.M.-L., T.A., C.M., I.P.-V., E.M.-H., H.A., D.E., S.L., J.D., F.G., A.S.), Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain; Division of Neurology (G.D.-G.), National Institute of Neurology and Neurosurgery, Mexico City; Pediatric Neuroimmunology Unit (T.A.), Neurology Service, Sant Joan de Deu Children's Hospital, University of Barcelona, Spain; Servicio de Inmunología (R.R.-G.), Centro de Diagnóstico Biomédico, Hospital Clinic of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.
Carmen MontejoFrom the Center of Neuroimmunology (M.S., G.D.-G., Y.B., N.S.-V., E.H.M.-L., T.A., C.M., I.P.-V., E.M.-H., H.A., D.E., S.L., J.D., F.G., A.S.), Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain; Division of Neurology (G.D.-G.), National Institute of Neurology and Neurosurgery, Mexico City; Pediatric Neuroimmunology Unit (T.A.), Neurology Service, Sant Joan de Deu Children's Hospital, University of Barcelona, Spain; Servicio de Inmunología (R.R.-G.), Centro de Diagnóstico Biomédico, Hospital Clinic of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.
Irene Pulido-ValdeolivasFrom the Center of Neuroimmunology (M.S., G.D.-G., Y.B., N.S.-V., E.H.M.-L., T.A., C.M., I.P.-V., E.M.-H., H.A., D.E., S.L., J.D., F.G., A.S.), Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain; Division of Neurology (G.D.-G.), National Institute of Neurology and Neurosurgery, Mexico City; Pediatric Neuroimmunology Unit (T.A.), Neurology Service, Sant Joan de Deu Children's Hospital, University of Barcelona, Spain; Servicio de Inmunología (R.R.-G.), Centro de Diagnóstico Biomédico, Hospital Clinic of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.
Eugenia Martinez-HernandezFrom the Center of Neuroimmunology (M.S., G.D.-G., Y.B., N.S.-V., E.H.M.-L., T.A., C.M., I.P.-V., E.M.-H., H.A., D.E., S.L., J.D., F.G., A.S.), Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain; Division of Neurology (G.D.-G.), National Institute of Neurology and Neurosurgery, Mexico City; Pediatric Neuroimmunology Unit (T.A.), Neurology Service, Sant Joan de Deu Children's Hospital, University of Barcelona, Spain; Servicio de Inmunología (R.R.-G.), Centro de Diagnóstico Biomédico, Hospital Clinic of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.
Helena AriñoFrom the Center of Neuroimmunology (M.S., G.D.-G., Y.B., N.S.-V., E.H.M.-L., T.A., C.M., I.P.-V., E.M.-H., H.A., D.E., S.L., J.D., F.G., A.S.), Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain; Division of Neurology (G.D.-G.), National Institute of Neurology and Neurosurgery, Mexico City; Pediatric Neuroimmunology Unit (T.A.), Neurology Service, Sant Joan de Deu Children's Hospital, University of Barcelona, Spain; Servicio de Inmunología (R.R.-G.), Centro de Diagnóstico Biomédico, Hospital Clinic of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.
Domingo EscuderoFrom the Center of Neuroimmunology (M.S., G.D.-G., Y.B., N.S.-V., E.H.M.-L., T.A., C.M., I.P.-V., E.M.-H., H.A., D.E., S.L., J.D., F.G., A.S.), Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain; Division of Neurology (G.D.-G.), National Institute of Neurology and Neurosurgery, Mexico City; Pediatric Neuroimmunology Unit (T.A.), Neurology Service, Sant Joan de Deu Children's Hospital, University of Barcelona, Spain; Servicio de Inmunología (R.R.-G.), Centro de Diagnóstico Biomédico, Hospital Clinic of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.
Raquel Ruiz-GarcíaFrom the Center of Neuroimmunology (M.S., G.D.-G., Y.B., N.S.-V., E.H.M.-L., T.A., C.M., I.P.-V., E.M.-H., H.A., D.E., S.L., J.D., F.G., A.S.), Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain; Division of Neurology (G.D.-G.), National Institute of Neurology and Neurosurgery, Mexico City; Pediatric Neuroimmunology Unit (T.A.), Neurology Service, Sant Joan de Deu Children's Hospital, University of Barcelona, Spain; Servicio de Inmunología (R.R.-G.), Centro de Diagnóstico Biomédico, Hospital Clinic of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.
Sara LlufriuFrom the Center of Neuroimmunology (M.S., G.D.-G., Y.B., N.S.-V., E.H.M.-L., T.A., C.M., I.P.-V., E.M.-H., H.A., D.E., S.L., J.D., F.G., A.S.), Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain; Division of Neurology (G.D.-G.), National Institute of Neurology and Neurosurgery, Mexico City; Pediatric Neuroimmunology Unit (T.A.), Neurology Service, Sant Joan de Deu Children's Hospital, University of Barcelona, Spain; Servicio de Inmunología (R.R.-G.), Centro de Diagnóstico Biomédico, Hospital Clinic of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.
Josep DalmauFrom the Center of Neuroimmunology (M.S., G.D.-G., Y.B., N.S.-V., E.H.M.-L., T.A., C.M., I.P.-V., E.M.-H., H.A., D.E., S.L., J.D., F.G., A.S.), Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain; Division of Neurology (G.D.-G.), National Institute of Neurology and Neurosurgery, Mexico City; Pediatric Neuroimmunology Unit (T.A.), Neurology Service, Sant Joan de Deu Children's Hospital, University of Barcelona, Spain; Servicio de Inmunología (R.R.-G.), Centro de Diagnóstico Biomédico, Hospital Clinic of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.
Francesc GrausFrom the Center of Neuroimmunology (M.S., G.D.-G., Y.B., N.S.-V., E.H.M.-L., T.A., C.M., I.P.-V., E.M.-H., H.A., D.E., S.L., J.D., F.G., A.S.), Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain; Division of Neurology (G.D.-G.), National Institute of Neurology and Neurosurgery, Mexico City; Pediatric Neuroimmunology Unit (T.A.), Neurology Service, Sant Joan de Deu Children's Hospital, University of Barcelona, Spain; Servicio de Inmunología (R.R.-G.), Centro de Diagnóstico Biomédico, Hospital Clinic of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain.
Albert SaizFrom the Center of Neuroimmunology (M.S., G.D.-G., Y.B., N.S.-V., E.H.M.-L., T.A., C.M., I.P.-V., E.M.-H., H.A., D.E., S.L., J.D., F.G., A.S.), Service of Neurology, Laboratory of Advanced Imaging in Neuroimmunological Diseases, Hospital Clínic of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), and Universitat de Barcelona, Barcelona, Spain; Division of Neurology (G.D.-G.), National Institute of Neurology and Neurosurgery, Mexico City; Pediatric Neuroimmunology Unit (T.A.), Neurology Service, Sant Joan de Deu Children's Hospital, University of Barcelona, Spain; Servicio de Inmunología (R.R.-G.), Centro de Diagnóstico Biomédico, Hospital Clinic of Barcelona, Spain; Department of Neurology (J.D.), University of Pennsylvania, Philadelphia, PA; and Catalan Institution for research and Advanced Studies (ICREA) (J.D.), Barcelona, Spain. asaiz@clinic.cat.
Institució Catalana de Recerca i Estudis Avançats · ES
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo describe the clinical features of late-onset (≥50 years) neuromyelitis optica spectrum disorder (LO-NMOSD), to compare the outcome with that of early-onset (EO-NMOSD), and to identify predictors of disability.
methodsA retrospective, multicenter study of 238 patients with NMOSD identified by the 2015 criteria. Clinical and immunologic features of patients with LO-NMOSD were compared with those with EO-NMOSD. All patients were evaluated for aquaporin-4 (AQP4-IgG) and myelin oligodendrocyte glycoprotein (MOG-IgG) antibodies.
resultsSixty-nine (29%) patients had LO-NMOSD. Demographic features, initial disease presentation, annualized relapse rate, and frequency of AQP4-IgG and MOG-IgG did not differ between patients with LO-NMOSD and EO-NMOSD. Among patients with AQP4-IgG or double seronegativity, those with LO-NMOSD had a higher risk to require a cane to walk (hazard ratio [HR], 2.10, 95% CI 1.3-3.54,
conclusionsPatients with LO-NMOSD have similar clinical presentation but worse outcome than EO-NMOSD when they are double seronegative or AQP4-IgG positive. Serostatus and residual disability after first attack are the main predictors of LO-NMOSD outcome.
Indexed as
Neuromyelitis OpticaAdolescentAdultAgedAged, 80 and overAge of OnsetAutoantibodiesChildFemaleHumansMaleMiddle AgedPersons with DisabilitiesPrognosisRetrospective StudiesYoung AdultAutoantibodies
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