Evidence map›Paper›PMID 31471359›Full record

ArticleBMJ case reports2019

Systemic mastocytosis: variable manifestations can lead to a challenging diagnostic process.

Susanna Nallamilli, Aideen O'Neill, Andrew Wilson, Mallika Sekhar, Jonathan Lambert

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Susanna NallamilliHaematology, University College London Hospitals NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-6080-601X
Aideen O'NeillHaematology, University College London Hospitals NHS Foundation Trust, London, UK.
Andrew WilsonHaematology, University College London Hospitals NHS Foundation Trust, London, UK.
Mallika SekharHaematology, University College London Hospitals NHS Foundation Trust, London, UK.
Jonathan LambertHaematology, University College London Hospitals NHS Foundation Trust, London, UK.
University College London Hospitals NHS Foundation Trust · GB

Funding

Medical Research Council MR/S000135/1
6 · The paper itself

Abstract

Systemic mastocytosis results from proliferation and activation of an abnormal mast cell clone. It is a heterogeneous disorder with clinical manifestations ranging from skin lesions alone to aggressive multi-organ infiltration and decreased survival. Given these varied manifestations, diagnosis can be difficult. We describe the case of a woman who presented with rash and diarrhoea and had a history of anaphylactic reactions. Over a protracted period, the patient's symptoms were investigated by a number of specialties including gastroenterology, dermatology, immunology and haematology. Morphological, immunohistochemical and molecular analysis of bone marrow samples ultimately led to a diagnosis of systemic mastocytosis. Management with leukotriene and histamine antagonists resulted in significant improvement in symptoms and quality of life. The case serves to highlight the protean manifestations of systemic mastocytosis, the tests available to diagnose it and the agents available to treat it.

Indexed as

AdultAnaphylaxisDiagnosis, DifferentialDiarrheaExanthemaFemaleHumansMastocytosis, Systemicgastrointestinal systemhaematology (incl blood transfusion)skin

Identifiers

PMID31471359
PMCPMC6721155
OpenAlexW2970958789

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.