ArticleScience immunology2019
Position β57 of I-A
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 52 citations in OpenAlex.
- A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes.Nature immunology · 2026Article
- A vascular-associated fibroblastic cell controls pancreatic islet immunity.Cell reports · 2025Article
- Type 1 Diabetes: A Guide to Autoimmune Mechanisms for Clinicians.Diabetes, obesity & metabolism · 2025Review
- A hierarchy of intestinal antigens instructs the CD4Immunity · 2025Article
- Clinical settings in which human leukocyte antigen typing is still useful in the diagnosis of celiac disease.World journal of gastroenterology · 2025Review
- Immunopeptidomics for autoimmunity: unlocking the chamber of immune secrets.NPJ systems biology and applications · 2025Review
- Crinophagic granules in pancreatic β cells contribute to mouse autoimmune diabetes by diversifying pathogenic epitope repertoire.Nature communications · 2024Article
- CXCL16-dependent scavenging of oxidized lipids by islet macrophages promotes differentiation of pathogenic CD8Immunity · 2024Article
- The immunology of type 1 diabetes.Nature reviews. Immunology · 2024Review
- De novo identification of CD4Nature methods · 2024Article
- Repositioning the Early Pathology of Type 1 Diabetes to the Extraislet Vasculature.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Autoimmune CD8+ T cells in type 1 diabetes: from single-cell RNA sequencing to T-cell receptor redirection.Frontiers in endocrinology · 2024Review
- Antigen-specific T cell responses in autoimmune diabetes.Frontiers in immunology · 2024Review
- Mapping of a hybrid insulin peptide in the inflamed islet β-cells from NOD mice.Frontiers in immunology · 2024Article
- Deletion of Vβ3Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Measuring anti-islet autoimmunity in mouse and human by profiling peripheral blood antigen-specific CD4 T cells.Science translational medicine · 2023Article
- Productive Germinal Center Responses Depend on the Nature of Stimuli Received by Anti-Insulin B Cells in Type 1 Diabetes-Prone Mice.ImmunoHorizons · 2023Article
- Chromogranin A-derived peptides pancreastatin and catestatin: emerging therapeutic target for diabetes.Amino acids · 2023Review
- I-ANature immunology · 2023Article
- Heterogeneity of Islet-Infiltrating IL-21+ CD4 T Cells in a Mouse Model of Type 1 Diabetes.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 1 country.
Louis GioiaDepartment of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-1302-2340
Marie HoltDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.
Anne CostanzoDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0003-1934-5319
Siddhartha SharmaDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0001-8597-7547
Brian AbeDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-1262-5556
Lisa KainDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA.
Maki NakayamaDepartment of Pediatrics and Department of Immunology and Microbiology, Barbara Davis Center for Diabetes, University of Colorado School of Medicine, Denver, CO 80045, USA.ORCID 0000-0002-0009-3687
Xiaoxiao WanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Andrew SuDepartment of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, CA 92037, USA.ORCID 0000-0002-9859-4104
Clayton MathewsDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA.ORCID 0000-0002-8817-6355
Yi-Guang ChenUniversity of Florida College of Medicine, Gainesville, FL 32611, USA.
Emil UnanueDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Luc TeytonDepartment of Immunology and Microbiology, Scripps Research Institute, La Jolla, CA 92037, USA. lteyton@scripps.edu.ORCID 0000-0002-4049-1583
Scripps Research Institute · USWashington University in St. Louis · USMedical College of Wisconsin · USUniversity of Colorado Health · USUniversity of Florida · US
Funding
Project 3P01AI042288 · NIAID · UNIVERSITY OF FLORIDA · PI Todd Michael Brusko · 1997 to 2026
$32.9MScripps Translational Science InstituteUL1TR002550 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2018 to 2022
$28.9MDIABETOGENIC MOLECULE I-AG7--CHEMISTRY AND BIOLOGYR01DK058177 · NIDDK · WASHINGTON UNIVERSITY · PI UNANUE, EMIL RAPHAEL · 2000 to 2020
$7.8MMultiple Autoantigens/Multiple Epitopes of Type 1DMR01DK032083 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MICHELS, AARON W · 1986 to 2025
$6.9MMechanistic and Therapeutic Role of the CD137-CD137L Axis in Type 1 DiabetesR01DK107541 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI CHEN, YI-GUANG, RIDGWAY, WILLIAM M · 2016 to 2025
$5.6MMolecular Dissection of Insulin Targeting in Anti-Islet AutoimmunityR01DK099317 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI AARON W MICHELS, Maki Nakayama · 2013 to 2026
$5.3MDiscovery and Functional Studies of Genes for T1D GWAS Susceptibility LociDP3DK097605 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI CHEN, YI-GUANG, GEURTS, ARON M · 2012 to 2012
$4.3MInsulin Specific T Cell Response Shaped by Diabetes Protective MHC Class II MoleculesR01DK108868 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI AARON W MICHELS · 2017 to 2026
$3.6MEarly diagnosis and mechanistic studies of type 1 diabetes using single cell analysisR01DK117138 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI TEYTON, LUC · 2019 to 2022
$3.2MScripps Translational Science InstituteKL2TR001112 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2013 to 2017
$3.0MAUTOIMMUNE DIABETES: EARLY EVENTS IN ISLETS OF LANGERHANSR01AI114551 · NIAID · WASHINGTON UNIVERSITY · PI UNANUE, EMIL RAPHAEL · 2015 to 2019
$2.1MIdentification of relevant peptides involved in the initiation and progression of autoimmune diabetesR01DK120340 · NIDDK · WASHINGTON UNIVERSITY · PI UNANUE, EMIL RAPHAEL · 2018 to 2021
$1.7MNCATS NIH HHS KL2 TR001112NCATS NIH HHS TL1 TR002551NCATS NIH HHS UL1 TR002550NIAID NIH HHS P01 AI042288NIAID NIH HHS R01 AI114551NIAID NIH HHS R21 AI110963NIAID NIH HHS R21 AI125879NIDDK NIH HHS DP3 DK097605NIDDK NIH HHS R01 DK032083NIDDK NIH HHS R01 DK058177NIDDK NIH HHS R01 DK099317NIDDK NIH HHS R01 DK107541NIDDK NIH HHS R01 DK108868NIDDK NIH HHS R01 DK117138NIDDK NIH HHS R01 DK120340NIDDK NIH HHS R01 DK121747
Abstract
The class II region of the major histocompatibility complex (MHC) locus is the main contributor to the genetic susceptibility to type 1 diabetes (T1D). The loss of an aspartic acid at position 57 of diabetogenic HLA-DQβ chains supports this association; this single amino acid change influences how TCRs recognize peptides in the context of HLA-DQ8 and I-A
Indexed as
AllelesAnimalsCD4-Positive T-LymphocytesCell LineDiabetes Mellitus, Type 1FemaleInsulinMajor Histocompatibility ComplexMiceMice, Inbred NODPeptidesReceptors, Antigen, T-CellInsulinPeptidesReceptors, Antigen, T-Cell
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.