Evidence map›Paper›PMID 31471215›Full record

ReviewTrends in parasitology2019

More than Microtubules: The Structure and Function of the Subpellicular Array in Trypanosomatids.

Amy N Sinclair, Christopher L de Graffenried

Open access · greenAbstract readReview
In one paragraph

Review in Trends in parasitology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 42 citations in OpenAlex.

  1. Cell Death and Unprecedent Cytoskeletal Changes inChemical & biomedical imaging · 2026
    Article
  2. Review
  3. Article
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  6. Review
  7. Article
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  10. Kharon Is Crucial forPathogens (Basel, Switzerland) · 2025
    Article
  11. Tubulin detyrosination shapesProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Meroterpenoids fromPharmaceuticals (Basel, Switzerland) · 2023
    Article
  16. Article
  17. Morphogenesis Dynamics in Leishmania Differentiation.Pathogens (Basel, Switzerland) · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Amy N SinclairDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.
Christopher L de GraffenriedDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA. Electronic address: Christopher_degraffenried@Brown.edu.
Brown University · US

Funding

The role of polo-like kinase in the duplication of the trypanosome cytoskeletonR01AI112953 · NIAID · BROWN UNIVERSITY · PI DE GRAFFENRIED, CHRISTOPHER LUIS · 2015 to 2019
$2.0M
The role of structural inheritance in the positioning of the T. brucei flagellumR21AI115089 · NIAID · BROWN UNIVERSITY · PI DE GRAFFENRIED, CHRISTOPHER LUIS · 2015 to 2016
$447k
The role of the subpellicular microtubule array in Trypanosoma brucei cytokinesisF31AI143163 · NIAID · BROWN UNIVERSITY · PI SINCLAIR, AMY · 2019 to 2020
$91k
NIAID NIH HHS F31 AI143163NIAID NIH HHS R01 AI112953NIAID NIH HHS R21 AI115089
6 · The paper itself

Abstract

The subpellicular microtubule array defines the wide range of cellular morphologies found in parasitic kinetoplastids (trypanosomatids). Morphological studies have characterized array organization, but little progress has been made towards identifying the molecular mechanisms that are responsible for array differentiation during the trypanosomatid life cycle, or the apparent stability and longevity of array microtubules. In this review, we outline what is known about the structure and biogenesis of the array, with emphasis on Trypanosoma brucei, Trypanosoma cruzi, and Leishmania, which cause life-threatening diseases in humans and livestock. We highlight unanswered questions about this remarkable cellular structure that merit new consideration in light of our recently improved understanding of how the 'tubulin code' influences microtubule dynamics to generate complex cellular structures.

Indexed as

MicrotubulesTrypanosomatinacorsetcytokinesismicrotubulesmorphologysubpellicular arrayTrypanosoma

Identifiers

PMID31471215
PMCPMC6783356
OpenAlexW2970251761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.