ArticleNeuron2019
A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila.
Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- Hunger recruits a parallel circuit encoding alcohol reward.Current biology : CB · 2026Article
- The brain of the female Anopheles gambiae mosquito at spatial and single-cell resolution.Nature communications · 2026Article
- Cellular and functional dissection of the octopaminergic and tyraminergic system in the Drosophila brain.Current biology : CB · 2026Article
- Hunger states modulate aggression via opposing dopamine pathways.Nature communications · 2026Article
- An octopamine-glutamate cotransmitting neuron gates aggressive escalation through layered inhibition inScience advances · 2026Article
- Systematic analysis of mushroom body-innervating dopaminergic neuron activity in different physiological states in Drosophila.Biomedical journal · 2026Article
- Two neuropeptides that promote blood feeding ineLife · 2026Article
- Octopamine regulates neural circuits in the mushroom body and central complex, influencing sleep and arousal.iScience · 2026Article
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- Hormonal control of postmitotic neuronal identity.bioRxiv : the preprint server for biology · 2026Article
- Re-exposure to reward re-evaluates related memories.Current biology : CB · 2026Article
- Convergence-divergence circuits for multimodal integration of innate and learned opponent valences.Frontiers in systems neuroscience · 2026Article
- Dual roles ofiScience · 2025Article
- Octopamine signaling regulates the intracellular pattern of the presynaptic active zone scaffold within Drosophila mushroom body neurons.PLoS biology · 2025Article
- The Oviposition Inhibitory Neuron is a Potential Hub of Multi-Circuit Integration in theeNeuro · 2025Article
- Sleep need-dependent plasticity of a thalamic circuit promotes homeostatic recovery sleep.Science (New York, N.Y.) · 2025Article
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- The role of dopamine in foraging decisions in social insects.Frontiers in insect science · 2025Review
14 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors.
Funding
Abstract
In pursuit of food, hungry animals mobilize significant energy resources and overcome exhaustion and fear. How need and motivation control the decision to continue or change behavior is not understood. Using a single fly treadmill, we show that hungry flies persistently track a food odor and increase their effort over repeated trials in the absence of reward suggesting that need dominates negative experience. We further show that odor tracking is regulated by two mushroom body output neurons (MBONs) connecting the MB to the lateral horn. These MBONs, together with dopaminergic neurons and Dop1R2 signaling, control behavioral persistence. Conversely, an octopaminergic neuron, VPM4, which directly innervates one of the MBONs, acts as a brake on odor tracking by connecting feeding and olfaction. Together, our data suggest a function for the MB in internal state-dependent expression of behavior that can be suppressed by external inputs conveying a competing behavioral drive.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.