Evidence map›Paper›PMID 31470858›Full record

ArticleCardiovascular diabetology2019

Epicardial adipose tissue predicts incident cardiovascular disease and mortality in patients with type 2 diabetes.

Regitse H Christensen, Bernt Johan von Scholten, Christian S Hansen, Magnus T Jensen, Tina Vilsbøll, Peter Rossing, Peter G Jørgensen

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 110 citations in OpenAlex.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Regitse H ChristensenCenter for Inflammation and Metabolism/Center for Physical Activity Research, Rigshospitalet, Copenhagen, Denmark. regitseh@gmail.com.ORCID 0000-0001-5316-5341
Bernt Johan von ScholtenSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Christian S HansenSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Magnus T JensenDepartment of Cardiology, Glostrup-Rigshospitalet, Glostrup, Denmark.
Tina VilsbøllSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Peter RossingSteno Diabetes Center Copenhagen, Gentofte, Denmark.
Peter G JørgensenDepartment of Cardiology, Herlev-Gentofte Hospital, Hellerup, Denmark.
Steno Diabetes Centers · DKUniversity of Copenhagen · DKGentofte Hospital · DKGlostrup Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac fat is a cardiovascular biomarker but its importance in patients with type 2 diabetes is not clear. The aim was to evaluate the predictive potential of epicardial (EAT), pericardial (PAT) and total cardiac (CAT) fat in type 2 diabetes and elucidate sex differences.

methodsEAT and PAT were measured by echocardiography in 1030 patients with type 2 diabetes. Follow-up was performed through national registries. The end-point was the composite of incident cardiovascular disease (CVD) and all-cause mortality. Analyses were unadjusted (model 1), adjusted for age and sex (model 2), plus systolic blood pressure, body mass index (BMI), low-density lipoprotein (LDL), smoking, diabetes duration and glycated hemoglobin (HbA

resultsMedian follow-up was 4.7 years and 248 patients (191 men vs. 57 women) experienced the composite end-point. Patients with high EAT (> median level) had increased risk of the composite end-point in model 1 [Hazard ratio (HR): 1.46 (1.13; 1.88), p = 0.004], model 2 [HR: 1.31 (1.01; 1.69), p = 0.038], and borderline in model 3 [HR: 1.32 (0.99; 1.77), p = 0.058]. For men, but not women, high EAT was associated with a 41% increased risk of CVD and mortality in model 3 (p = 0.041). Net reclassification index improved when high EAT was added to model 3 (19.6%, p = 0.035). PAT or CAT were not associated with the end-point.

conclusionHigh levels of EAT were associated with the composite of incident CVD and mortality in patients with type 2 diabetes, particularly in men, after adjusting for CVD risk factors. EAT modestly improved risk prediction over CVD risk factors.

Indexed as

AdiposityAdipose TissueAgedCardiovascular DiseasesDenmarkDiabetes Mellitus, Type 2EchocardiographyFemaleHumansIncidenceMaleMiddle AgedPericardiumPredictive Value of TestsPrognosisProspective StudiesCardiovascular diseaseEpicardial adipose tissuePericardial adipose tissueRisk prediction

Identifiers

PMID31470858
PMCPMC6716926
OpenAlexW2970906936

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.