ArticleMolecules (Basel, Switzerland)2019
Identification of New Antifungal Agents Targeting Chitin Synthesis by a Chemical-Genetic Method.
Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Antifungal treatment strategies and their impact on resistance development in clinical settings.The Journal of antimicrobial chemotherapy · 2025Review
- Clinical Isolate ofOpen journal of medical microbiology · 2025Article
- Antifungal activity of a maleimide derivative: disruption of cell membranes and interference with iron ion homoeostasis.Mycology · 2025Article
- Comprehensive genome-scale metabolic model of the human pathogenFrontiers in bioinformatics · 2023Article
- Identification of lncRNA and weighted gene coexpression network analysis of germinatingMycology · 2023Article
- Solid-State NMR Investigations of Extracellular Matrixes and Cell Walls of Algae, Bacteria, Fungi, and Plants.Chemical reviews · 2022Review
- Solid-state NMR analysis of unlabeled fungal cell walls fromJournal of structural biology: X · 2022Article
- Prospects for anti-Cell surface (Amsterdam, Netherlands) · 2021Review
- Inhibitory effect of berberine hydrochloride against Candida albicans and the role of the HOG-MAPK pathway.The Journal of antibiotics · 2021Article
- Structural Polymorphism of Chitin and Chitosan in Fungal Cell Walls From Solid-State NMR and Principal Component Analysis.Frontiers in molecular biosciences · 2021Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Fungal infection is a leading cause of mortality in immunocompromised population; thus, it is urgent to develop new and safe antifungal agents. Different from human cells, fungi have a cell wall, which is composed mainly of polysaccharide glucan and chitin. The unique cell wall structure is an ideal target for antifungal drugs. In this research, a chemical-genetic method was used to isolate antifungal agents that target chitin synthesis in yeast cells. From a compound library, we isolated two benzothiazole compounds that showed greater toxicity to yeast mutants lacking glucan synthase Fks1 compared to wild-type yeast cells and mutants lacking chitin synthase Chs3. Both of them inhibited the activity of chitin synthase in vitro and reduced chitin level in yeast cells. Besides, these compounds showed clear synergistic antifungal effect with a glucan synthase inhibitors caspofungin. Furthermore, these compounds inhibited the growth of
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