ArticleCells2019
Protein S100-A7 Derived from Digested Dentin Is a Critical Molecule for Dentin Pulp Regeneration.
Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Differential Expression of S100A Genes in hDPSCs Following Stimulation with Two Hydraulic Calcium Silicate Cements: A Laboratory Investigation.Journal of functional biomaterials · 2026Article
- Telomeres in skin aging.Biogerontology · 2025Review
- Sex-specific modulating role of social support in the associations between oxidative stress, inflammation, and telomere length in older adults.Journal of behavioral medicine · 2024Article
- CD146, a therapeutic target involved in cell plasticity.Science China. Life sciences · 2024Review
- Poly(Aspartic Acid) Promotes Odontoblast-like Cell Differentiation in Rat Molars with Exposed Pulp.Journal of functional biomaterials · 2023Article
- Dentin Degradation: From Tissue Breakdown to Possibilities for Therapeutic Intervention.Current oral health reports · 2023Article
- Cell-scaffold interactions in tissue engineering for oral and craniofacial reconstruction.Bioactive materials · 2023Article
- Dopamine is involved in reparative dentin formation through odontoblastic differentiation of dental pulp stem cells.Scientific reports · 2023Article
- Novel Functional Peptide for Next-Generation Vital Pulp Therapy.Journal of dental research · 2023Article
- Physiologic dentin regeneration: its past, present, and future perspectives.Frontiers in physiology · 2023Review
- The Genes Involved in Dentinogenesis.Organogenesis · 2022Article
- Effect of PCL/nHAEA nanocomposite to osteo/odontogenic differentiation of dental pulp stem cells.BMC oral health · 2022Article
- Performance of a Biodegradable Composite with Hydroxyapatite as a Scaffold in Pulp Tissue Repair.Polymers · 2020Article
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dentin consists of inorganic hard tissue and organic dentin matrix components (DMCs). Various kinds of bioactive molecules are included in DMCs and some of them can be released after digestion by endogenous matrix metalloproteinases (MMPs) in the caries region. Digested DMCs induced by MMP20 have been reported to promote pulpal wound healing processes, but the released critical molecules responsible for this phenomenon are unclear. Here, we identified protein S100-A7 as a critical molecule for pulpal healing in digested DMCs by comprehensive proteomic approaches and following pulp capping experiments in rat molars. In addition, immunohistochemical results indicated the specific distribution of S100-A7 and receptor for advanced glycation end-products (RAGE) as receptor for S100-A7 in the early stage of the pulpal healing process, and following accumulation of CD146-positive stem cells in wounded pulp. Our findings indicate that protein S100-A7 released from dentin by MMP20 might play a key role in dentin pulp regeneration.
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Registered trials
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