Evidence map›Paper›PMID 31470614›Full record

ArticleMarine drugs2019

Characterization, Recombinant Production and Structure-Function Analysis of NvCI, A Picomolar Metallocarboxypeptidase Inhibitor from the Marine Snail

Giovanni Covaleda-Cortés, Martha Hernández, Sebastián Alejandro Trejo, Manuel Mansur, Sergi Rodríguez-Calado, Javier García-Pardo, Julia Lorenzo, Josep Vendrell, María Ángeles Chávez, Maday Alonso-Del-Rivero and 1 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Targeting carboxypeptidase A/B activity with the phosphinic inhibitor C28 reduces the asthmatic response in a mouse model of house dust mite-induced asthma.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Giovanni Covaleda-CortésInstitute of Biotechnology and Biomedicine and Departament of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain.
Martha HernándezFaculty of Forestry Science, Biotechnology Center, Universidad de Concepción, Victoria 631, Barrio Universitario, 2407 Concepción, Chile.
Sebastián Alejandro TrejoInstitute of Biotechnology and Biomedicine and Departament of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain.ORCID 0000-0003-2866-5613
Manuel MansurInstitute of Biotechnology and Biomedicine and Departament of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain.
Sergi Rodríguez-CaladoInstitute of Biotechnology and Biomedicine and Departament of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain.ORCID 0000-0002-8849-1101
Javier García-PardoInstitute of Biotechnology and Biomedicine and Departament of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain.ORCID 0000-0001-9179-6371
Julia LorenzoInstitute of Biotechnology and Biomedicine and Departament of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain. Julia.Lorenzo@uab.cat.ORCID 0000-0001-5659-6008
Josep VendrellInstitute of Biotechnology and Biomedicine and Departament of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain.
María Ángeles ChávezCenter for Protein Research, Faculty of Biology, Universidad de la Habana, 10400 La Habana, Cuba.
Maday Alonso-Del-RiveroCenter for Protein Research, Faculty of Biology, Universidad de la Habana, 10400 La Habana, Cuba. maday@fbio.uh.cu.ORCID 0000-0003-1988-6852
Francesc Xavier AvilésInstitute of Biotechnology and Biomedicine and Departament of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Barcelona), Spain. FrancescXavier.Aviles@uab.es.ORCID 0000-0002-1399-6789
Universitat Autònoma de Barcelona · ESUniversity of Havana · CUUniversity of Concepción · CL

Funding

Ministerio de Economía y Competitividad BIO2016 78057-R
6 · The paper itself

Abstract

A very powerful proteinaceous inhibitor of metallocarboxypeptidases has been isolated from the marine snail

Indexed as

Amino Acid SequenceAnimalsAquatic OrganismsBase SequenceBinding SitesCloning, MolecularDNA, ComplementaryHumansProteinsSnailsSubstrate SpecificityDNA, ComplementaryProteinsbiotechnological and biomedical applicationscarboxypeptidaseNerita versicolorpicomolar inhibitionproteinaceous inhibitorrecombinant production

Identifiers

PMID31470614
PMCPMC6780499
OpenAlexW2971120752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.