ReviewPharmaceuticals (Basel, Switzerland)2019
Multilevel Impacts of Iron in the Brain: The Cross Talk between Neurophysiological Mechanisms, Cognition, and Social Behavior.
Review in Pharmaceuticals (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Age and sex-based impacts of maternal iron deficiency on offspring's cognitive function and anemia: A systematic review.European journal of clinical nutrition · 2024Pooled it
- Iron quantification in basal ganglia: quantitative susceptibility mapping as a potential biomarker for Alzheimer's disease - a systematic review and meta-analysis.Frontiers in neuroscience · 2024Pooled it
- Iron dysregulation in the central nervous system: implications for autism spectrum disorder.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Associations between anemia and postpartum depression among Arab Bedouin women.BMC pregnancy and childbirth · 2026Article
- Iron Homeostasis and Reproduction: Unveiling the Microbiome-Gut-Brain Axis Connection in the MosquitoCells · 2026Article
- Ferroptosis in Neuropsychiatric and Neurodegenerative Disorders: Shared Mechanisms and Disease-Specific Signatures.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Targeting ferroptosis as a novel strategy for depressive mental disorders.Psychopharmacology · 2026Review
- Psychosocial Impairment and Micronutrient Deficiencies in Indian Adolescents: A Pilot Study.Cureus · 2026Article
- Sex-Specific Differences in Dietary Iron Intake and Sleep Disorder in NHANES 2005-2014 Population.Food science & nutrition · 2026Article
- The Relationship Between Trace Elements and Depression.Nutrients · 2026Review
- Effect of iron supplementation on brain myelination and neurodevelopmental outcomes in children aged 0-3 years: a systematic review protocol.Frontiers in pediatrics · 2026Article
- Efficacy of vitamin/mineral supplement on children with Down syndrome and autism spectrum disorder.International journal of developmental disabilities · 2026Article
- Climate change, health and environmental policy in Africa: structural constraints, regional disparities and global inequities.Frontiers in public health · 2026Review
- Serotransferrin enhances transferrin receptor-mediated brain uptake of antibodies.Drug delivery and translational research · 2025Article
- Exploring age-related iron dysregulation: effects on longevity, body size, and behavior in C. elegans.Experimental gerontology · 2025Article
- Iron, Emotion, and Awareness: Exploring Alexithymia and Anxiety in Anemic Women.Medicina (Kaunas, Lithuania) · 2025Article
- Unraveling the nutritional challenges in epilepsy: Risks, deficiencies, and management strategies: A systematic review.World journal of experimental medicine · 2025Article
- Subcortical brain iron and its link to verbal memory in children with developmental language disorder.Brain and language · 2025Article
- Serum iron as a biomarker for "penumbra freezing" in patients with acute ischemic stroke.Frontiers in neuroscience · 2025Article
- Prefrontal cortex iron content in neurodegeneration and healthy subjects: A systematic review.Ibrain · 2025Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Iron is a critical element for most organisms, which plays a fundamental role in the great majority of physiological processes. So much so, that disruption of iron homeostasis has severe multi-organ impacts with the brain being particularly sensitive to such modifications. More specifically, disruption of iron homeostasis in the brain can affect neurophysiological mechanisms, cognition, and social behavior, which eventually contributes to the development of a diverse set of neuro-pathologies. This article starts by exploring the mechanisms of iron action in the brain and follows with a discussion on cognitive and behavioral implications of iron deficiency and overload and how these are framed by the social context. Subsequently, we scrutinize the implications of the disruption of iron homeostasis for the onset and progression of psychosocial disorders. Lastly, we discuss the links between biological, psychological, and social dimensions and outline potential avenues of research. The study of these interactions could ultimately contribute to a broader understanding of how individuals think and act under physiological and pathophysiological conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.