Evidence map›Paper›PMID 31470261›Full record

ArticleRedox biology2019

Using MRI to measure in vivo free radical production and perfusion dynamics in a mouse model of elevated oxidative stress and neurogenic atrophy.

Bumsoo Ahn, Nataliya Smith, Debra Saunders, Rojina Ranjit, Parker Kneis, Rheal A Towner, Holly Van Remmen

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  5. Review
  6. Article
  7. Mouse models of sarcopenia: classification and evaluation.Journal of cachexia, sarcopenia and muscle · 2021
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Bumsoo AhnAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Nataliya SmithAdvanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Debra SaundersAdvanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Rojina RanjitAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Parker KneisAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Rheal A TownerAdvanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Pathology and Pharmaceutical Sciences, OUHSC, Oklahoma City, OK, USA; Oklahoma Nathan Shock Center for Aging, Oklahoma City, OK, USA.
Holly Van RemmenAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Physiology, OUHSC, Oklahoma City, OK, USA; Oklahoma City VA Medical Center, Oklahoma City, OK, USA; Oklahoma Nathan Shock Center for Aging, Oklahoma City, OK, USA. Electronic address: Holly-VanRemmen@omrf.org.
Oklahoma Medical Research Foundation · USUniversity of Oklahoma Health Sciences Center · US

Funding

Targeted DNA Methylation and Mitochondrial Heteroplasmy CoreP30AG050911 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Veronica Galvan, Benjamin Francis Miller · 2015 to 2026
$13.9M
PROJECT 3: Neuromuscular redox homeostasis in mice lacking SOD1 and aging wild type mice subcontract at University of LiverpoolP01AG051442 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROOKS, SUSAN V · 2016 to 2020
$8.9M
Defining the relative roles of pre- and post-synaptic events in the initiation and progression of sarcopeniaR01AG050676 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROOKS, SUSAN V, VAN REMMEN, HOLLY · 2016 to 2020
$3.3M
Causes, consequences, imaging and mitigation of sepsis-induced encephalopathyR01NS092458 · NINDS · UNIVERSITY OF UTAH · PI HOFFMAN, JOHN M, MORTON, KATHRYN ANN · 2015 to 2019
$2.9M
Pre-Clinical 7T MRI for OklahomaS10OD023508 · OD · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI TOWNER, RHEAL A · 2017 to 2017
$600k
NIA NIH HHS P01 AG051442NIA NIH HHS P30 AG050911NIA NIH HHS R01 AG050676NIH HHS S10 OD023508NINDS NIH HHS R01 NS092458
6 · The paper itself

Abstract

Mitochondrial dysfunction, reactive oxygen species (ROS) and oxidative damage have been implicated to play a causative role in age-related skeletal muscle atrophy and weakness (i.e. sarcopenia). Mice lacking the superoxide scavenger CuZnSOD (Sod1

Indexed as

Magnetic Resonance ImagingMolecular ImagingOxidative StressAnimalsDisease Models, AnimalFree RadicalsMiceMice, KnockoutMuscle, SkeletalMuscular AtrophyOxidation-ReductionReactive Oxygen SpeciesFree RadicalsReactive Oxygen Species

Identifiers

PMID31470261
PMCPMC6831885
OpenAlexW2969640044

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.