ArticleCryobiology2019
Effects of exercise in a cold environment on gene expression for mitochondrial biogenesis and mitophagy.
Article in Cryobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Can Vitamin D supplementation enhance the effectiveness of exercise-induced weight loss in overweight or obese adults? Evidence from integrated transcriptomic and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Treating Metabolic Dysregulation and Senescence by Caloric Restriction: Killing Two Birds with One Stone?Antioxidants (Basel, Switzerland) · 2025Review
- Cold exposure and the cardiovascular system: from physiological adaptation to pathological risk.Frontiers in physiology · 2025Review
- No Mitochondrial Related Transcriptional Changes in Human Skeletal Muscle after Local Heat Application.International journal of environmental research and public health · 2022Article
- Influence of Local Muscle Cooling on Mitochondrial-Related Gene Expression at Rest.International journal of environmental research and public health · 2022Article
- Rifaximin Protects against Malathion-Induced Rat Testicular Toxicity: A Possible Clue on Modulating Gut Microbiome and Inhibition of Oxidative Stress by Mitophagy.Molecules (Basel, Switzerland) · 2022Article
- Molecular Mechanisms of Exercise and Healthspan.Cells · 2022Review
- Angiostatic freeze or angiogenic move? Acute cold stress prevents angiokine secretion from murine myotubes but primes primary endothelial cells for greater migratory capacity.Frontiers in physiology · 2022Article
- Effect of local heat application during exercise on gene expression related to mitochondrial homeostasis.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2021Article
- The Acute Effects of Exercise and Temperature on Regional mtDNA.International journal of environmental research and public health · 2021Article
- Effect of local cold application during exercise on gene expression related to mitochondrial homeostasis.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2021Article
- Exercise- and Cold-Induced HumanInternational journal of environmental research and public health · 2020Article
- Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Cold exposure during cycling and recovery enhances PGC-1α transcription, but aspects of mitophagy and a more intense cold exposure without recovery occurring in the cold have not been explored. PURPOSE: Determine the expression of genes related to mitochondrial biogenesis and mitophagy following an acute cycling bout at a temperature below freezing compared to that of room temperature.
methodsEleven male participants cycled at 65% W
resultsExercising heart rate and skin temperature were lower in the cold (p < 0.001; p = 0.004), while core temperature was higher (p = 0.016). Temperature had no effect on gene expression (p > 0.05). BNIP3 and BNIP3L mRNA were not influenced by exercise (p = 0.329; p 0.233). PGC-1α and VEGF were higher after cycling (p < 0.001), but the extent of PGC-1α upregulation was reduced 6 h post-exercise (p 0.006). TFAM increased 6 h post-exercise (p = 0.001). NRF2, ERRα, PINK1, and PARK2 decreased 3 h post-exercise (p 0.035; p = 0.005; p = 0.002; p = 0.001), but this downregulation was diminished after 6 h of recovery (p = 0.017; p 0.006; p = 0.043; p = 0.047). NRF1 was marginally attenuated with exercise (p = 0.001).
conclusionsExercise induced alterations in gene expression for mitochondrial biogenesis and mitophagy, but these effects were independent of temperature.
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