ArticleInternational journal for numerical methods in biomedical engineering2019
Computational instantaneous wave-free ratio (IFR) for patient-specific coronary artery stenoses using 1D network models.
Article in International journal for numerical methods in biomedical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Non-invasive Computational Techniques for Diagnosing Myocardial Ischemia: Challenges and Future of FFRAnnals of biomedical engineering · 2026Review
- Uncertainty Quantification and Sensitivity Analysis for Non-invasive Model-Based Instantaneous Wave-Free Ratio Prediction.International journal for numerical methods in biomedical engineering · 2025Article
- Article
- A novel, patient-tailored method for non-invasive iFRCT measurement.Cardiology journal · 2024Article
- Computational fluid dynamics modeling of coronary artery blood flow using OpenFOAM: Validation with the food and drug administration benchmark nozzle model.Journal of X-ray science and technology · 2024Article
- A multi-stage neural network approach for coronary 3D reconstruction from uncalibrated X-ray angiography images.Scientific reports · 2023Article
- The Continuum of Invasive Techniques for the Assessment of Intermediate Coronary Lesions.Diagnostics (Basel, Switzerland) · 2022Review
- A predictive patient-specific computational model of coronary artery bypass grafts for potential use by cardiac surgeons to guide selection of graft configurations.Frontiers in cardiovascular medicine · 2022Article
- Artificial intelligence approaches to predict coronary stenosis severity using non-invasive fractional flow reserve.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2020Article
- Comparison of Instantaneous Wave-Free Ratio (iFR) and Fractional Flow Reserve (FFR) with respect to Their Sensitivities to Cardiovascular Factors: A Computational Model-Based Study.Journal of interventional cardiology · 2020Article
- Computational instantaneous wave-free ratio (IFR) for patient-specific coronary artery stenoses using 1D network models.International journal for numerical methods in biomedical engineering · 2019Article
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4 authors.
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Abstract
In this work, we estimate the diagnostic threshold of the instantaneous wave-free ratio (iFR) through the use of a one-dimensional haemodynamic framework. To this end, we first compared the computed fractional flow reserve (cFFR) predicted from a 1D computational framework with invasive clinical measurements. The framework shows excellent promise and utilises minimal patient data from a cohort of 52 patients with a total of 66 stenoses. The diagnostic accuracy of the cFFR model was 75.76%, with a sensitivity of 71.43%, a specificity of 77.78%, a positive predictive value of 60%, and a negative predictive value of 85.37%. The validated model was then used to estimate the diagnostic threshold of iFR. The model determined a quadratic relationship between cFFR and the ciFR. The iFR diagnostic threshold was determined to be 0.8910 from a receiver operating characteristic curve that is in the range of 0.89 to 0.9 that is normally reported in clinical studies.
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