ArticlePloS one2019
Predicting vaccine effectiveness in livestock populations: A theoretical framework applied to PRRS virus infections in pigs.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- Helminthic Infections and Vaccine Efficacy in Cattle: Implications for Disease Control and Sustainable Livestock Production.Veterinary sciences · 2025Review
- Article
- PRRSV-Vaccinated, Seronegative Sows and Maternally Derived Antibodies (I): Impact on PRRSV-1 Challenge Outcomes in Piglets.Vaccines · 2023Article
- Litters of Various-Sized Mummies (LVSM) and Stillborns after Porcine Reproductive and Respiratory Syndrome Virus Type 1 Infection-A Case Report.Veterinary sciences · 2023Article
- Dynamics of Feline Coronavirus and FIP: A Compartmental Modeling Approach.Veterinary medicine international · 2023Article
- What is a biosecurity measure? A definition proposal for animal production and linked processing operations.One health (Amsterdam, Netherlands) · 2022Review
- Optimal experimental designs for estimating genetic and non-genetic effects underlying infectious disease transmission.Genetics, selection, evolution : GSE · 2022Article
- Modeling suggests gene editing combined with vaccination could eliminate a persistent disease in livestock.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Why DoesFrontiers in immunology · 2022Review
- Review: Livestock disease resilience: from individual to herd level.Animal : an international journal of animal bioscience · 2021Review
- Risk Factors for Positivity to Shiga Toxin-ProducingInternational journal of environmental research and public health · 2021Article
- Modeling of Vaccination and Contact Tracing as Tools to Control the COVID-19 Outbreak in Spain.Vaccines · 2021Article
- Commercial PRRS Modified-Live Virus Vaccines.Vaccines · 2021Review
- Article
- Vaccination Is a Suitable Tool in the Control of Aujeszky's Disease Outbreaks in Pigs Using a Population Dynamics P Systems Model.Animals : an open access journal from MDPI · 2020Article
- Pathogen transmission from vaccinated hosts can cause dose-dependent reduction in virulence.PLoS biology · 2020Article
- Modelling infectious viral diseases in swine populations: a state of the art.Porcine health management · 2020Review
- Modeling Economic Effects of Vaccination Against Porcine Reproductive and Respiratory Syndrome: Impact of Vaccination Effectiveness, Vaccine Price, and Vaccination Coverage.Frontiers in veterinary science · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Vaccines remain one of the main tools to control infectious diseases in domestic livestock. Although a plethora of veterinary vaccines are on the market and routinely applied to protect animals against infection with particular pathogens, the disease in question often continues to persist, sometimes at high prevalence. The limited effectiveness of certain vaccines in the field leaves open questions regarding the required properties that an effective vaccine should have, as well as the most efficient vaccination strategy for achieving the intended goal of vaccination programmes. To date a systematic approach for studying the combined effects of different types of vaccines and vaccination strategies is lacking. In this paper, we develop a theoretical framework for modelling the epidemiological consequences of vaccination with imperfect vaccines of various types, administered using different strategies to herds with different replacement rates and heterogeneity in vaccine responsiveness. Applying the model to the Porcine Reproductive and Respiratory Syndrome (PRRS), which despite routine vaccination remains one of the most significant endemic swine diseases worldwide, we then examine the influence of these diverse factors alone and in combination, on within-herd virus transmission. We derive threshold conditions for preventing infection invasion in the case of imperfect vaccines inducing limited sterilizing immunity. The model developed in this study has practical implications for the development of vaccines and vaccination programmes in livestock populations not only for PRRS, but also for other viral infections primarily transmitted by direct contact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.