ArticleNeuroreport2019
EphA4 receptor regulates outwardly rectifying chloride channel in CA1 hippocampal neurons after ischemia-reperfusion.
Article in Neuroreport, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- Treadmill Training-Induced Remyelination Rescues Cognitive Impairment After Acute Hypoxia.Neurochemical research · 2025Article
- Possible Involvement of DNA Methylation in TSC1 Gene Expression in Neuroprotection Induced by Hypoxic Preconditioning.Oxidative medicine and cellular longevity · 2022Article
- Effect of electroacupuncture on glial fibrillary acidic protein and nerve growth factor in the hippocampus of rats with hyperlipidemia and middle cerebral artery thrombus.Neural regeneration research · 2021Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CA1 hippocampal neurons are sensitive to ischemia. The erythropoietin-producing hepatocellular carcinoma (Eph) receptors are a cell-cell contact signaling pathway for regulating neuron function and death. However, the mechanisms of EphA receptor in neuron death after ischemia remain unclear. In this study, we present evidence that outwardly rectifying chloride channels reside in CA1 hippocampal neurons. EphA4 receptor increased chloride channel currents. Moreover, the EphA4 receptor no longer had significant effects on enhanced channel currents following ischemia-reperfusion. Inhibition of EphA4 receptor with EphA4-Fc significantly decreased the channel currents after ischemia-reperfusion. These results suggest that the increased effect of the EphA4 receptor on the outwardly rectifying chloride channel activity in CA1 hippocampal neurons may provide better treatment for ischemic brain injury.
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