Evidence map›Paper›PMID 31469558›Full record

ArticleJournal of the American Chemical Society2019

Labeling and Natural Post-Translational Modification of Peptides and Proteins via Chemoselective Pd-Catalyzed Prenylation of Cysteine.

Thomas Schlatzer, Julia Kriegesmann, Hilmar Schröder, Melanie Trobe, Christian Lembacher-Fadum, Simone Santner, Alexander V Kravchuk, Christian F W Becker, Rolf Breinbauer

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Ultrafast Au(III)-Mediated Arylation of Cysteine.Journal of the American Chemical Society · 2024
    Article
  9. Article
  10. Recent Advances in Bioorthogonal Ligation and Bioconjugation.Topics in current chemistry (Cham) · 2023
    Review
  11. Constraining and Modifying Peptides Using Pd-Mediated Cysteine Allylation.Chembiochem : a European journal of chemical biology · 2023
    Article
  12. Article
  13. Article
  14. Chemische Synthese und Semisynthese von lipidierten Proteinen.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2022
    Review
  15. Chemical Synthesis and Semisynthesis of Lipidated Proteins.Angewandte Chemie (International ed. in English) · 2022
    Review
  16. Amphiphilic Iodine(III) Reagents for the Lipophilization of Peptides in Water.Angewandte Chemie (International ed. in English) · 2021
    Article
  17. An Organometallic Strategy for Cysteine Borylation.Journal of the American Chemical Society · 2021
    Article
  18. Oligonucleotide Bioconjugation with Bifunctional Palladium Reagents.Angewandte Chemie (International ed. in English) · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Thomas SchlatzerInstitute of Organic Chemistry , Graz University of Technology , Stremayrgasse 9 , A-8010 Graz , Austria.
Julia KriegesmannInstitute of Biological Chemistry, Faculty of Chemistry , University of Vienna , Währinger Strasse 38 , A-1090 Vienna , Austria.
Hilmar SchröderInstitute of Organic Chemistry , Graz University of Technology , Stremayrgasse 9 , A-8010 Graz , Austria.
Melanie TrobeInstitute of Organic Chemistry , Graz University of Technology , Stremayrgasse 9 , A-8010 Graz , Austria.
Christian Lembacher-FadumInstitute of Organic Chemistry , Graz University of Technology , Stremayrgasse 9 , A-8010 Graz , Austria.
Simone SantnerInstitute of Organic Chemistry , Graz University of Technology , Stremayrgasse 9 , A-8010 Graz , Austria.
Alexander V KravchukInstitute of Biological Chemistry, Faculty of Chemistry , University of Vienna , Währinger Strasse 38 , A-1090 Vienna , Austria.
Christian F W BeckerInstitute of Biological Chemistry, Faculty of Chemistry , University of Vienna , Währinger Strasse 38 , A-1090 Vienna , Austria.ORCID 0000-0002-8890-7082
Rolf BreinbauerInstitute of Organic Chemistry , Graz University of Technology , Stremayrgasse 9 , A-8010 Graz , Austria.ORCID 0000-0001-6009-7359
Graz University of Technology · ATUniversity of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prenylation of peptides and proteins is an important post-translational modification observed in vivo. We report that the Pd-catalyzed Tsuji-Trost allylation with a Pd/BIPHEPHOS catalyst system allows the allylation of Cys-containing peptides and proteins with complete chemoselectivity and high

Indexed as

Protein Processing, Post-TranslationalCatalysisCysteinePalladiumPeptidesPrenylationProteinsCysteinePalladiumPeptidesProteins

Identifiers

PMID31469558
PMCPMC6776382
OpenAlexW2970846538

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.