ArticleInternational journal of cancer2020
Identification of novel epithelial ovarian cancer loci in women of African ancestry.
Open access · bronzeAbstract read
In one paragraph
Article in International journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 29% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Identification of lncRNAs Deregulated in Epithelial Ovarian Cancer Based on a Gene Expression Profiling Meta-Analysis.International journal of molecular sciences · 2023Pooled it
- Large trans-ethnic meta-analysis identifies AKR1C4 as a novel gene associated with age at menarche.Human reproduction (Oxford, England) · 2021Pooled it
- Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer.NPJ genomic medicine · 2025Article
- An Analytic Pipeline to Obtain Reliable Genetic Ancestry Estimates from Tumor-Derived RNA Sequencing Data.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Health care access domains and treatment as mediators of ovarian cancer racial disparities in survival: a structural equation modeling analysis in SEER-Medicare.American journal of epidemiology · 2025Article
- Association ofGynecology and pelvic medicine · 2025Article
- Comparative transcriptomic, epigenomic and immunological analyses identify drivers of disparity in high-grade serous ovarian cancer.NPJ genomic medicine · 2024Article
- Article
- Fine-scale mapping of chromosome 9q22.33 identifies candidate causal variant in ovarian cancer.PeerJ · 2024Article
- Lymphatic vasculature in ovarian cancer.Biochimica et biophysica acta. Reviews on cancer · 2023Review
- Quiescent Ovarian Cancer Cells Secrete Follistatin to Induce Chemotherapy Resistance in Surrounding Cells in Response to Chemotherapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Article
- Survival of epithelial ovarian cancer in Black women: a society to cell approach in the African American cancer epidemiology study (AACES).Cancer causes & control : CCC · 2023Article
- Molecular Management of High-Grade Serous Ovarian Carcinoma.International journal of molecular sciences · 2022Review
- Genome-Wide Association Study of Fluorescent Oxidation Products Accounting for Tobacco Smoking Status in Adults from the French EGEA Study.Antioxidants (Basel, Switzerland) · 2022Article
- Polygenic risk modeling for prediction of epithelial ovarian cancer risk.European journal of human genetics : EJHG · 2022Article
- Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry.Journal of the National Cancer Institute · 2021Article
- Genetically predicted circulating protein biomarkers and ovarian cancer risk.Gynecologic oncology · 2021Article
- Race and Ethnicity Influence Survival Outcomes in Women of Caribbean Nativity With Epithelial Ovarian Cancer.Frontiers in oncology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
44 authors at 20 institutions in 3 countries.
Ani ManichaikulCenter for Public Health Genomics, University of Virginia, Charlottesville, VA.
Lauren C PeresDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA.ORCID 0000-0002-6620-8600
Xin-Qun WangDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA.
Mollie E BarnardHuntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, UT.
Deanna ChynDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA.
Xin ShengDepartment of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA.
Zhaohui DuDepartment of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA.ORCID 0000-0002-7125-8928
Jonathan TyrerStrangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom.
Joseph DennisStrangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom.
Ann G SchwartzKarmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI.
Michele L CoteKarmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI.
Edward PetersEpidemiology Program, Louisiana State University Health Sciences Center School of Public Health, New Orleans, LA.
Patricia G MoormanDepartment of Community and Family Medicine, Duke University Medical Center, Durham, NC.
Melissa BondyCancer Prevention and Population Sciences Program, Baylor College of Medicine, Houston, TX.
Jill S Barnholtz-SloanDepartment of Population and Quantitative Health Sciences and Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH.ORCID 0000-0001-6190-9304
Paul TerryDepartment of Medicine, University of Tennessee Medical Center - Knoxville, Knoxville, TN.
Anthony J AlbergDepartment of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC.
Elisa V BanderaDepartment of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ.
Ellen FunkhouserDivision of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL.
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA.
Celeste Leigh PearceDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI.ORCID 0000-0002-8023-7846
Malcom PikeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA.ORCID 0000-0003-4891-1199
Veronica Wendy SetiawanDepartment of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA.
African American Breast Cancer Consortium (AABC)
African Ancestry Prostate Cancer Consortium (AAPC)
Julie R PalmerSlone Epidemiology Center at Boston University, Boston, MA.
Loic LeMarchandUniversity of Hawaii Cancer Center, Honolulu, HI.
Lynne R WilkensUniversity of Hawaii Cancer Center, Honolulu, HI.
Andrew BerchuckDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC.
Jennifer A DohertyHuntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, UT.
Francesmary ModugnoDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA.ORCID 0000-0003-0637-1534
Roberta NessThe University of Texas School of Public Health, Houston, TX.
Kirsten MoysichDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY.
Beth Y KarlanDepartment of Obstetrics and Gynecology, Ronald Regan UCLA Medical Center, Los Angeles, CA.
Alice S WhittemoreDepartment of Health Research and Policy, Stanford University School of Medicine, Stanford, CA.
Valerie McGuireDepartment of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA.
Weiva SiehDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, NY, New York.
Kate LawrensonDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA.ORCID 0000-0002-6469-2515
Simon GaytherCenter for Bioinformatics and Functional Genomics and the Cedars-Sinai Genomics Core, Cedars-Sinai Medical Center, Los Angeles, CA.
Thomas A SellersDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.
Paul PharoahStrangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom.
Joellen M SchildkrautDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA.ORCID 0000-0002-0990-9339
African American Cancer Epidemiology Study (AACES) and the Ovarian Cancer Association Consortium (OCAC)
Keck Hospital of USC · USUniversity of Virginia Health System · USUniversity of Cambridge · GBCedars-Sinai Medical Center · USUniversity of Hawaiʻi at Mānoa · USUniversity of Southern California · USUniversity of Utah · USWayne State University · USBaylor College of Medicine · USBoston University · USCase Western Reserve University · USDuke Medical Center · USDuke University · USIcahn School of Medicine at Mount Sinai · USLouisiana State University Health Sciences Center New Orleans · USMoffitt Cancer Center · USRonald Reagan UCLA Medical Center · USRoswell Park Comprehensive Cancer Center · USRutgers, The State University of New Jersey · USStanford Health Care · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MUSC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4MWomen's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI AKHILESH PANDEY · 1985 to 2026
$151.3MUCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MUse of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI ELLEN L. GOODE · 2009 to 2026
$37.0MGENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2MMultiethnic Cohort Study of Diet and CancerR37CA054281 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI KOLONEL, LAURENCE N. · 2003 to 2012
$23.2MCancer Research UK 10119Cancer Research UK 16561Intramural NIH HHS Z01 ES044005Intramural NIH HHS Z01 ES049033NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NCI NIH HHS K00 CA212222NCI NIH HHS K07 CA080668NCI NIH HHS K99 CA218681NCI NIH HHS N01 CN025403NCI NIH HHS N01 PC067010NCI NIH HHS P01 CA017054NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA071789NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA105009NCI NIH HHS P50 CA136393NCI NIH HHS P50 CA159981NCI NIH HHS R00 CA218681NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA054419NCI NIH HHS R01 CA058598NCI NIH HHS R01 CA058860NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA076016NCI NIH HHS R01 CA087538NCI NIH HHS R01 CA095023NCI NIH HHS R01 CA112523NCI NIH HHS R01 CA122443NCI NIH HHS R01 CA126841NCI NIH HHS R01 CA142081NCI NIH HHS R01 CA149429NCI NIH HHS R01 CA160669NCI NIH HHS R01 CA200854NCI NIH HHS R03 CA113148NCI NIH HHS R03 CA115195NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA069417NCI NIH HHS U01 CA164973NCI NIH HHS U19 CA148112NCI NIH HHS UM1 CA164973NCI NIH HHS UM1 CA176726NCI NIH HHS UM1 CA186107NCRR NIH HHS S10 RR025141Wellcome Trust
Abstract
Women of African ancestry have lower incidence of epithelial ovarian cancer (EOC) yet worse survival compared to women of European ancestry. We conducted a genome-wide association study in African ancestry women with 755 EOC cases, including 537 high-grade serous ovarian carcinomas (HGSOC) and 1,235 controls. We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10
Indexed as
Aldo-Keto Reductase Family 1 Member C3Antigens, NeoplasmBlack or African AmericanBlack PeopleBreast NeoplasmsCarcinoma, Ovarian EpithelialFemaleFollistatinGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansNeoplasm ProteinsPolymorphism, Single NucleotideUnited StatesWhite PeopleAKR1C3 protein, humanAldo-Keto Reductase Family 1 Member C3Antigens, NeoplasmFollistatinFST protein, humanMAGEC1 protein, humanNeoplasm ProteinsAfrican ancestryeQTLsgene expressiongenome wide association studyovarian cancer
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.