Evidence map›Paper›PMID 31469332›Full record

ArticleFuture medicinal chemistry2019

Benzimidazole inhibitors of the major cysteine protease of

Glaécia An Pereira, Lucianna H Santos, Steven C Wang, Luan C Martins, Filipe S Villela, Weiting Liao, Marco A Dessoy, Luiz C Dias, Adriano D Andricopulo, Mariana Af Costa and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 4 countries.

Glaécia An PereiraLaboratório de Modelagem Molecular e Planejamento de Fármacos, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.
Lucianna H SantosLaboratório de Modelagem Molecular e Planejamento de Fármacos, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.
Steven C WangCenter for Discovery & Innovation in Parasitic Diseases, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
Luan C MartinsLaboratório de Modelagem Molecular e Planejamento de Fármacos, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.
Filipe S VillelaLaboratório de Modelagem Molecular e Planejamento de Fármacos, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.
Weiting LiaoCenter for Discovery & Innovation in Parasitic Diseases, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
Marco A DessoyInstituto de Química, Departamento de Química Orgânica, Universidade Estadual de Campinas, C.P. 6154, Campinas, SP 13084-971, Brazil.
Luiz C DiasInstituto de Química, Departamento de Química Orgânica, Universidade Estadual de Campinas, C.P. 6154, Campinas, SP 13084-971, Brazil.
Adriano D AndricopuloLaboratório de Química Medicinal e Computacional, Instituto de Física da USP-São Carlos, Av. João Dagnone 1100, São Carlos, SP 13563-120, Brazil.
Mariana Af CostaDepartamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.
Ronaldo Ap NagemDepartamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.
Conor R CaffreyCenter for Discovery & Innovation in Parasitic Diseases, Skaggs School of Pharmacy & Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA 92093, USA.
Klaus R LiedlInstitute of General, Inorganic & Theoretical Chemistry, & Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 82, Innsbruck, Tyrol, 6020, Austria.
Ernesto R CaffarenaGrupo de Biofísica Computacional e Modelagem Molecular, Programa de Computação Científica (PROCC). Fundação Oswaldo Cruz, Av. Brasil 4365, Rio de Janeiro, RJ 21040-360, Brazil.
Rafaela S FerreiraLaboratório de Modelagem Molecular e Planejamento de Fármacos, Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, MG 31270-901, Brazil.ORCID 0000-0003-3324-0601
Universidade Federal de Minas Gerais · BRUniversity of California San Diego · USUniversidade Estadual de Campinas (UNICAMP) · BRFundação Oswaldo Cruz · BRUniversität Innsbruck · AT

Funding

Brain Penetrant Microtubule-Stabilizers to treat CNS-invasive parasitic diseasesR21AI133394 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BALLATORE, CARLO, CAFFREY, CONOR · 2018 to 2019
$426k
NIAID NIH HHS R21 AI133394
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

BenzimidazolesCysteine ProteasesCysteine Proteinase InhibitorsDose-Response Relationship, DrugStructure-Activity RelationshipTrypanocidal AgentsTrypanosoma brucei bruceiTrypanosomiasis, AfricanbenzimidazoleBenzimidazolesCysteine ProteasesCysteine Proteinase InhibitorsTrypanocidal Agentsbenzimidazole inhibitorscruzainparasite cysteine proteasesrhodesain

Identifiers

PMID31469332
PMCPMC6722484
OpenAlexW2970108342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.