Evidence map›Paper›PMID 31469055›Full record

ArticleTissue engineering. Part A2020

3D-Printed Ceramic-Demineralized Bone Matrix Hyperelastic Bone Composite Scaffolds for Spinal Fusion.

J Adam Driscoll, Ryan Lubbe, Adam E Jakus, Kevin Chang, Meraaj Haleem, Chawon Yun, Gurmit Singh, Andrew D Schneider, Karina M Katchko, Carmen Soriano and 8 more

Open access · greenAbstract read
In one paragraph

Article in Tissue engineering. Part A, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 53 citations in OpenAlex.

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  11. Review
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  13. Recent advances of 3D-printing in spine surgery.Surgical neurology international · 2024
    Review
  14. Advances in Synthetic Grafts in Spinal Fusion Surgery.International journal of spine surgery · 2023
    Article
  15. Article
  16. Article
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  18. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 1 country.

J Adam DriscollDepartment of Orthopaedic Surgery, Northwestern University, Chicago, Illinois.
Ryan LubbeDepartment of Orthopaedic Surgery, Northwestern University, Chicago, Illinois.
Adam E JakusSimpson Querrey Institute, Chicago, Illinois.
Kevin ChangDepartment of Orthopaedic Surgery, Northwestern University, Chicago, Illinois.
Meraaj HaleemDepartment of Orthopaedic Surgery, Northwestern University, Chicago, Illinois.
Chawon YunDepartment of Orthopaedic Surgery, Northwestern University, Chicago, Illinois.
Gurmit SinghDepartment of Orthopaedic Surgery, Northwestern University, Chicago, Illinois.
Andrew D SchneiderDepartment of Orthopaedic Surgery, Northwestern University, Chicago, Illinois.
Karina M KatchkoDepartment of Orthopaedic Surgery, Northwestern University, Chicago, Illinois.
Carmen SorianoArgonne National Laboratory, Argonne, Illinois.
Michael NewtonOrthopaedic Research Laboratory, Beaumont Health, Royal Oak, Michigan.
Tristan MaerzOrthopaedic Research Laboratory, Beaumont Health, Royal Oak, Michigan.
Xin LiSimpson Querrey Institute, Chicago, Illinois.
Kevin BakerOrthopaedic Research Laboratory, Beaumont Health, Royal Oak, Michigan.
Wellington K HsuDepartment of Orthopaedic Surgery, Northwestern University, Chicago, Illinois.
Ramille N ShahSimpson Querrey Institute, Chicago, Illinois.
Stuart R StockSimpson Querrey Institute, Chicago, Illinois.
Erin L HsuDepartment of Orthopaedic Surgery, Northwestern University, Chicago, Illinois.
Northwestern University · USArgonne National Laboratory · USBeaumont Health · USOakland University · USUniversity of Michigan–Ann Arbor · US

Funding

3-D Printed Hyperelastic Bone Composites for Bone Regeneration and Spine FusionR01AR069580 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HSU, ERIN L. · 2016 to 2019
$1.3M
NIAMS NIH HHS R01 AR069580
6 · The paper itself

Abstract

Although numerous spinal biologics are commercially available, a cost-effective and safe bone graft substitute material for spine fusion has yet to be proven. In this study, "3D-Paints" containing varying volumetric ratios of hydroxyapatite (HA) and human demineralized bone matrix (DBM) in a poly(lactide-co-glycolide) elastomer were three-dimensional (3D) printed into scaffolds to promote osteointegration in rats, with an end goal of spine fusion without the need for recombinant growth factor. Spine fusion was evaluated by manual palpation, and osteointegration and

Indexed as

Printing, Three-DimensionalAnimalsBone SubstitutesDurapatiteHumansRatsRats, Sprague-DawleySpinal FusionX-Ray MicrotomographyBone SubstitutesDurapatite3D printingdemineralized bone matrixhydroxyapatiteosteointegrationspine fusion

Identifiers

PMID31469055
PMCPMC7044791
OpenAlexW2970411740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.