ArticleAnnals of clinical and translational neurology2019
Spectral organization of focal seizures within the thalamotemporal network.
Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Nucleus-specific thalamic involvement in seizure networks differentiates neuromodulation outcomes.medRxiv : the preprint server for health sciences · 2026Article
- Thalamocortical network dynamics in focal epilepsy: SEEG investigation.bioRxiv : the preprint server for biology · 2026Article
- Thalamocortical seizure onset patterns in drug-resistant focal epilepsy.Brain communications · 2026Article
- Anterior nucleus of thalamus deep brain stimulation for medication refractory epilepsy modulates theta and low-frequency gamma activity: a case study.Therapeutic advances in neurological disorders · 2025Article
- The Reciprocal Relationship between Sleep and Epilepsy.Journal of personalized medicine · 2024Review
- Anterior thalamic nucleus local field potentials during focal temporal lobe epileptic seizures.Frontiers in neurology · 2024Article
- The anterior nucleus of the thalamus plays a role in the epileptic network.Annals of clinical and translational neurology · 2022Article
- Closed-Loop Brain Stimulation and Paradigm Shifts in Epilepsy Surgery.Neurologic clinics · 2022Review
- Time-Series Generative Adversarial Network Approach of Deep Learning Improves Seizure Detection From the Human Thalamic SEEG.Frontiers in neurology · 2022Article
- Article
- Invasive Electrophysiology for Circuit Discovery and Study of Comorbid Psychiatric Disorders in Patients With Epilepsy: Challenges, Opportunities, and Novel Technologies.Frontiers in human neuroscience · 2021Article
- Acute modulation of the limbic network with low and high-frequency stimulation of the human fornix.Epilepsy & behavior reports · 2020Article
- Directed Connectivity Analysis of the Neuro-Cardio- and Respiratory Systems Reveals Novel Biomarkers of Susceptibility to SUDEP.IEEE open journal of engineering in medicine and biology · 2020Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo investigate dynamic changes in neural activity between the anterior nucleus of the thalamus (ANT) and the seizure onset zone (SOZ) in patients with drug-resistant temporal lobe epilepsy (TLE) based on anatomic location, seizure subtype, and state of vigilance (SOV).
methodsEleven patients undergoing stereoelectroencephalography for seizure localization were recruited prospectively for local field potential (LFP) recording directly from the ANT. The SOZ was identified using line length and epileptogenicity index. Changes in power spectral density (PSD) were compared between the two anatomic sites as seizures (N = 53) transitioned from interictal baseline to the posttermination stage.
resultsAt baseline, the thalamic LFPs were significantly lower and distinct from the SOZ with the presence of higher power in the fast ripple band (P < 0.001). Temporal changes in ictal power of neural activity within ANT mimic those of the SOZ, are increased significantly at seizure onset (P < 0.05), and are distinct for seizures that impaired awareness or that secondarily generalized (P < 0.05). The onset of seizure was preceded by a decrease in the mean power spectral density (PSD) in ANT and SOZ (P < 0.05). Neural activity correlated with different states of vigilance at seizure onset within the ANT but not in the SOZ (P = 0.005).
interpretationThe ANT can be recruited at the onset of mesial temporal lobe seizures, and the recruitment pattern differs with seizure subtypes. Furthermore, changes in neural dynamics precede seizure onset and are widespread to involve temporo-thalamic regions, thereby providing an opportunity to intervene early with closed-loop DBS.
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