Evidence map›Paper›PMID 31468471›Full record

ArticleJournal of neurovirology2020

Monocyte activation, HIV, and cognitive performance in East Africa.

L Arnoldo Muñoz-Nevárez, Brandon M Imp, Michael A Eller, Francis Kiweewa, Jonah Maswai, Christina Polyak, Omalla Allan Olwenyi, I Elaine Allen, Eric Rono, Benedetta Milanini and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of neurovirology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Plasma Inflammatory Biomarkers Link to Worse Cognition Among Africans With HIV.Journal of acquired immune deficiency syndromes (1999) · 2025
    Article
  3. Article
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  5. Article
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  7. Observational
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  12. Sex Differences in the Treatment of HIV.Current HIV/AIDS reports · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

L Arnoldo Muñoz-NevárezGlobal Brain Health Institute, University of California, San Francisco, USA.
Brandon M ImpDepartment of Medicine, Kaiser Permanente San Francisco Medical Center, San Francisco, USA.
Michael A EllerU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, USA.
Francis KiweewaMakerere University Walter Reed Project, Kampala, Uganda.
Jonah MaswaiU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, USA.
Christina PolyakU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, USA.
Omalla Allan OlwenyiMakerere University Walter Reed Project, Kampala, Uganda.
I Elaine AllenGlobal Brain Health Institute, University of California, San Francisco, USA.
Eric RonoU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, USA.
Benedetta MilaniniMemory and Aging Center MC: 1207, Department of Neurology, University of California, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, 94158, USA.
Hannah KibuukaMakerere University Walter Reed Project, Kampala, Uganda.
Julie A AkeU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, USA.
Leigh Anne EllerU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, USA.
Victor G ValcourGlobal Brain Health Institute, University of California, San Francisco, USA. Vvalcour@memory.ucsf.edu.
Walter Reed Army Institute of Research · USMakerere University Walter Reed Project · UGGlobal Brain Health Institute · USUniversity Memory and Aging Center · USHenry M. Jackson Foundation · USKaiser Permanente San Francisco Medical Center · USUnited States Army Medical Research Directorate - Africa · KE

Funding

Midcareer Mentoring Award for Patient-Oriented Research in HIV and CognitionK24MH098759 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VALCOUR, VICTOR · 2013 to 2017
$887k
NIMH NIH HHS K24 MH098759PEPFAR
6 · The paper itself

Abstract

Chronic inflammation associated with monocyte activation has been linked to HIV-related cognitive outcomes in resource-rich settings. Few studies have investigated this relationship in the African context where endemic non-HIV infections may modulate effects. We characterized immune activation biomarkers in Kenyan and Ugandan participants in relation to neuropsychological testing performance (NTP) from the African Cohort Study (AFRICOS). We focused on activation markers associated with monocytes (sCD14, sCD163, neopterin), T cells (HLA-DR

Indexed as

CognitionAdultAfrica, EasternAgedAntigens, CDAntigens, Differentiation, MyelomonocyticBiomarkersCD163 AntigenCohort StudiesFemaleHIV InfectionsHumansLipopolysaccharide ReceptorsMaleMiddle AgedMonocytesAntigens, CDAntigens, Differentiation, MyelomonocyticBiomarkersCD163 AntigenLipopolysaccharide ReceptorsReceptors, Cell SurfaceCognition disordersEastern AfricaHIVIntestinal fatty acid-binding proteinsCD14sCD163

Identifiers

PMID31468471
PMCPMC7044045
OpenAlexW2970171183

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.