Evidence map›Paper›PMID 31468364›Full record

ArticleSleep & breathing = Schlaf & Atmung2020

Dose-dependent effects of mandibular advancement on optimal positive airway pressure requirements in obstructive sleep apnoea.

Ahmad A Bamagoos, Danny J Eckert, Kate Sutherland, Joachim Ngiam, Peter A Cistulli

Abstract read
PubMed Publisher
In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Maximizing outcomes by multimodal treatment in obstructive sleep apnea: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Upper airway collapsibility in patients with OSA treated with continuous positive airway pressure: a retrospective preliminary study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020
    Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Ahmad A BamagoosSleep Research Group, Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Camperdown, Australia. abam7287@uni.sydney.edu.au.ORCID http://orcid.org/0000-0001-7142-081X
Danny J EckertSleep and Breathing Group, Neuroscience Research Australia (NeuRA), Randwick, Australia.
Kate SutherlandSleep Research Group, Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Camperdown, Australia.
Joachim NgiamSleep Research Group, Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Camperdown, Australia.
Peter A CistulliSleep Research Group, Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Camperdown, Australia.
The University of Sydney · AUFlinders University · AU

Funding

King Abdulaziz University Scholarships for PhD StudiesNational Health and Medical Research Council 1116942SomnoMed In-kind support
6 · The paper itself

Abstract

backgroundImplementation of mandibular advancement splint (MAS) therapy as first-line treatment for obstructive sleep apnoea (OSA) is hindered by inter-individual variability of treatment outcomes and lack of robust patient selection methods. Optimal continuous positive airway pressure (CPAP) requirement provides an estimate of airway collapsibility severity, and high CPAP requirements predict MAS therapy failure in retrospective studies. Thus, understanding the effects of mandibular advancement on optimal CPAP requirements may enhance optimisation of patient selection for MAS therapy.

objectiveThis study aims to determine dose-dependent effects of mandibular advancement on optimal CPAP requirements in OSA.

methodsPrior to MAS therapy initiation, participants with OSA (apnoea-hypopnea index (AHI) > 10 events/h) underwent a research polysomnogram in which a remotely controlled mandibular positioner (RCMP) was used to determine dose-response effects of varying mandibular advancement positions (0% 'habitual bite' and 25, 50, 75 and 100% of maximum mandibular advancement, in random order) on optimal CPAP requirements. A separate polysomnography determined treatment outcome. Data are presented as mean ± SD or median (1st-3rd quartiles).

resultsSeventeen participants (age = 47 ± 9 years, body mass index = 26 kg/m

conclusionsIncreasing mandibular advancement lowers optimal CPAP requirements in a dose-dependent manner. This supports prior work indicating a beneficial effect of MAS on upper airway collapsibility.

Indexed as

AdultBody Mass IndexContinuous Positive Airway PressureFemaleHumansMaleMandibleMandibular AdvancementMiddle AgedOcclusal SplintsPolysomnographyRetrospective StudiesSleep Apnea SyndromesTreatment OutcomeOral appliancesSleep-disordered breathingTargeted treatment

Identifiers

PMID31468364
OpenAlexW2970260204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.