ArticleGeroScience2019
Validation of a geropathology grading system for aging mouse studies.
Article in GeroScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- End-of-life pathology in UM-HET3 mice treated with 16 α‑hydroxyestradiol or late‑start canagliflozin.GeroScience · 2026Article
- The gerotherapeutic drugs rapamycin, acarbose, and phenylbutyrate extend lifespan and enhance healthy aging in house crickets.Research square · 2026Article
- The effect of bempedoic acid on histopathologic changes associated with natural aging in rat lungs.BMC pulmonary medicine · 2025Article
- Chlamydia muridarum Causes Persistent Subclinical Infection and Elicits Innate and Adaptive Immune Responses in C57BL/6J, BALB/cJ, and J:ARC(S) Mice Following Exposure to Shedding Mice.Comparative medicine · 2024Article
- Prevalence and Pathologic Characterization of Mouse Kidney Parvovirus in Sentinel CD1 Mice.Comparative medicine · 2024Article
- Investigating the Suitability of Mare's Milk-Derived Exosomes as Potential Drug Carriers.Biomolecules · 2024Article
- Article
- Animal Models Relevant for Geroscience: Current Trends and Future Perspectives in Biomarkers, and Measures of Biological Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Review
- A machine learning approach for quantifying age-related histological changes in the mouse kidney.GeroScience · 2024Article
- Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction.Nature aging · 2024Article
- Article
- Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction.Research square · 2023Article
- Prolonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice.Cell metabolism · 2023Article
- Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice.GeroScience · 2023Article
- Reemergence of the Murine Bacterial PathogenComparative medicine · 2022Article
- Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate delays aging phenotypes in mice.Scientific reports · 2022Article
- Sex Matters in Aging. The Canagliflozin Story.Aging pathobiology and therapeutics · 2022Article
- Geropathology. An inside view of biological aging.Aging pathobiology and therapeutics · 2022Article
- PathoClock and PhysioClock in mice recapitulate human multimorbidity and heterogeneous aging.Aging pathobiology and therapeutics · 2021Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
An understanding of early-onset mechanisms underlying age-related changes can be obtained by evaluating changes that precede frailty and end of life using histological characterization of age-related lesions. Histopathology-based information as a component of aging studies in mice can complement and add context to molecular, cellular, and physiologic data, but there is a lack of information regarding scoring criteria and lesion grading guidelines. This report describes the validation of a grading system, designated as the geropathology grading platform (GGP), which generated a composite lesion score (CLS) for comparison of histological lesion scores in tissues from aging mice. To assess reproducibility of the scoring system, multiple veterinary pathologists independently scored the same slides from the heart, lung, liver, and kidney from two different strains (C57BL/6 and CB6F1) of male mice at 8, 16, 24, and 32 months of age. There was moderate to high agreement between pathologists, particularly when agreement within a 1-point range was considered. CLS for all organs was significantly higher in older versus younger mice, suggesting that the GGP was reliable for detecting age-related pathology in mice. The overall results suggest that the GGP guidelines reliably distinguish between younger and older mice and may therefore be accurate in distinguishing between experimental groups of mice with more, or less, age-related pathology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.