ArticleDigestive diseases and sciences2020
Increased Risk of Acute Pancreatitis with Codeine Use in Patients with a History of Cholecystectomy.
Article in Digestive diseases and sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Pain Management in Acute Pancreatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Frontiers in medicine · 2021Pooled it
- Codeine-induced pancreatitis in a previously Cholecystectomized patient: double the trouble.Oxford medical case reports · 2026Article
- Extracellular vesicle therapy for acute pancreatitis: experimental validation of mesenchymal stem cell-derived nanovesicles.BMC pharmacology & toxicology · 2025Article
- Morphologic Severity of Acute Pancreatitis on Imaging Is Independently Associated with Opioid Dose Requirements in Hospitalized Patients.Digestive diseases and sciences · 2022Article
- Heroin-Induced Acute Pancreatitis.Cureus · 2021Article
- Paradoxical Pain from Opioids: Increased Risk of Acute Pancreatitis.Digestive diseases and sciences · 2020Article
- Management of Severe Acute Pancreatitis.Current treatment options in gastroenterology · 2020Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCodeine has a spasmodic effect on sphincter of Oddi and is suspected to cause acute pancreatitis in patients with a history of cholecystectomy.
aimsTo assess the association between codeine use and acute pancreatitis in patients with a previous cholecystectomy.
methodsWe conducted a retrospective nested case-control study using the 2005-2015 MarketScan
resultsOf the 664,083 patients included in the cohort, 1707 patients were hospitalized for acute pancreatitis (incidence 1.1 per 1000 person-years) and were matched to 17,063 controls. Compared with non-use of codeine, use of codeine was associated with an increased risk of acute pancreatitis (OR 2.67; 95% CI 1.63, 4.36), particularly elevated in the first 15 days of codeine use (OR 5.37; 95% CI 2.70, 10.68). Compared with use of NSAIDs, use of codeine was also associated with an increased risk of acute pancreatitis (OR 2.64; 95% CI 1.54, 4.52).
conclusionCodeine is associated with an increased risk of acute pancreatitis in patients who have previously undergone cholecystectomy; greater clinician awareness of this association is needed.
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