Evidence map›Paper›PMID 31468182›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

In vivo imaging of synaptic loss in Alzheimer's disease with [18F]UCB-H positron emission tomography.

Christine Bastin, Mohamed Ali Bahri, François Meyer, Marine Manard, Emma Delhaye, Alain Plenevaux, Guillaume Becker, Alain Seret, Christine Mella, Fabrice Giacomelli and 4 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Cerebellar cortical amyloid deposition biasesEuropean journal of nuclear medicine and molecular imaging · 2026
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  13. Imaging Synaptic Density in Aging and Alzheimer Disease with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  14. Review
  15. Review
  16. SV2A PET shows hippocampal synaptic loss in cognitively unimpaired APOE ε4/ε4 homozygotes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  17. Article
  18. Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  19. Article
  20. GMP-compliant automated radiosynthesis of [EJNMMI radiopharmacy and chemistry · 2024
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Christine BastinGIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000, Liege, Belgium. Christine.Bastin@uliege.be.ORCID 0000-0002-4556-9490
Mohamed Ali BahriGIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000, Liege, Belgium.
François MeyerGIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000, Liege, Belgium.
Marine ManardGIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000, Liege, Belgium.
Emma DelhayeGIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000, Liege, Belgium.
Alain PlenevauxGIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000, Liege, Belgium.
Guillaume BeckerGIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000, Liege, Belgium.
Alain SeretGIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000, Liege, Belgium.
Christine MellaGIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000, Liege, Belgium.
Fabrice GiacomelliGIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000, Liege, Belgium.
Christian DegueldreGIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000, Liege, Belgium.
Evelyne BalteauGIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000, Liege, Belgium.
André LuxenGIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000, Liege, Belgium.
Eric SalmonGIGA-Cyclotron Research Center-in vivo imaging, University of Liège, Allée du 6 Août, B30, 4000, Liege, Belgium.
University of Liège · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLoss of brain synapses is an early pathological feature of Alzheimer's disease. The current study assessed synaptic loss in vivo with positron emission tomography and an 18F-labelled radiotracer of the synaptic vesicle protein 2A, [18F]UCB-H.

methodsTwenty-four patients with mild cognitive impairment or Alzheimer's disease and positive [18F]Flutemetamol amyloid-PET were compared to 19 healthy controls. [18F]UCB-H brain uptake was quantified with Logan graphical analysis using an image-derived blood input function. SPM12 and regions-of-interest (ROI) analyses were used for group comparisons of regional brain distribution volumes and for correlation with cognitive measures.

resultsA significant decrease of [18F]UCB-H uptake was observed in several cortical areas (11 to 18% difference) and in the thalamus (16% difference), with the largest effect size in the hippocampus (31% difference). Reduced hippocampal uptake was related to patients' cognitive decline (ROI analysis) and unawareness of memory problems (SPM and ROI analyses).

conclusionsThe findings thus highlight predominant synaptic loss in the hippocampus, confirming previous autopsy-based studies and a recent PET study with an 11C-labelled SV2A radiotracer. [18F]UCB-H PET allows to image in vivo synaptic changes in Alzheimer's disease and to relate them to patients' cognitive impairment.

Indexed as

Alzheimer DiseaseCognitive DysfunctionAnimalsBrainHippocampusHumansPositron-Emission TomographyAlzheimer’s diseaseBiomarkerPathophysiologyPET imagingSynaptic loss

Identifiers

PMID31468182
OpenAlexW2943930324

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.