ArticleEuropean journal of applied physiology2019
Passive force and viscoelastic properties of single fibers in human aging muscles.
Article in European journal of applied physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Effects of age on human skeletal muscle: a systematic review and meta-analysis of myosin heavy chain isoform protein expression, fiber size, and distribution.American journal of physiology. Cell physiology · 2024Pooled it
- Systematic review of skeletal muscle passive mechanics experimental methodology.Journal of biomechanics · 2021Pooled it
- Integrated Opto-Biomechatronics For Single Muscle Fibre Structure-Function Assessment: The MyoRobot 3.0.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Sex-specific effects of fatiguing exercise on skeletal muscle passive mechanics are preserved in aging.bioRxiv : the preprint server for biology · 2026Article
- The crossroads between osteosarcopenia and intrinsic capacity-a narrative review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Review
- Multiscale analysis of mechanical stress in muscle under static and dynamic loading.Biophysics reports · 2025Article
- Chronic and acute mediators of passive viscoelasticity in human skeletal muscle fibres.Experimental physiology · 2025Article
- Echoes of Muscle Aging: The Emerging Role of Shear Wave Elastography in Sarcopenia Diagnosis.Diagnostics (Basel, Switzerland) · 2025Review
- Glycerol storage increases passive stiffness of muscle fibers through effects on titin extensibility.The Journal of general physiology · 2025Article
- The role of physical activity in mitigating age-related changes in the neuromuscular control of gait.npj aging · 2025Article
- The effect of storing fiber, fiber bundle, and whole muscle in glycerinated solution on their passive elastic modulus.Scientific reports · 2025Article
- Aging-associated differences between perioral and trunk muscle characteristics.Scientific reports · 2024Article
- Fatiguing exercise reduces cellular passive Young's modulus in human vastus lateralis muscle.Experimental physiology · 2024Article
- The effects of 6-week home-based static stretching, dynamic stretching, or eccentric exercise interventions on muscle-tendon properties and functional performance in older women.Journal of exercise science and fitness · 2024Article
- Predicting myosin heavy chain isoform from postdissection fiber length in human skeletal muscle fibers.American journal of physiology. Cell physiology · 2024Article
- The effect of fatty infiltration, revision surgery, and sex on lumbar multifidus passive mechanical properties.JOR spine · 2023Article
- Skeletal muscle aging and sarcopenia: Perspectives from mechanical studies of single permeabilized muscle fibers.Journal of biomechanics · 2023Review
- Structure-Function relationships in the skeletal muscle extracellular matrix.Journal of biomechanics · 2023Review
- The impact of age-related increase in passive muscle stiffness on simulated upper limb reaching.Royal Society open science · 2023Article
- Single muscle fibre contractile function with ageing.The Journal of physiology · 2022Review
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
Abstract
purposeChanges in stiffness or extensibility of the muscle or muscle-tendon unit with aging could lead to impaired function and an increased vulnerability to injury. We aimed to investigate the passive force and viscoelastic properties of single muscle fibers in older adults.
methodsSeven older adults (mean age 79.0 ± 3.8 years) and 10 young control (mean age 25.6 ± 4.5 years) were recruited. Biopsy specimens were obtained percutaneously from m. vastus lateralis and skinned single fibers were used for the experiments. Slack tests were performed to determine maximal force and maximal unloaded shortening velocity. Passive force was measured in pCa 9.0 solution using a stepwise stretch technique with increment of sarcomere length from 2.4 to 4.2 µm. Myosin heavy chain (MHC) isoform was determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Specific force was calculated as maximal force divided by cross-sectional area. Passive force, peak passive force, time to half stress relaxation (T
resultsNo difference between the groups were found in specific force and shortening velocity. Passive force and peak passive force were greater in both MHC I and IIa fibers of older adults (p < 0.001, p = 0.012, respectively, at 4.2 mm SL). Force decay index was higher in older adults. (p = 0.001 at 4.2 µm SL). There were no significant differences in passive force and viscoelastic properties between fiber types.
conclusionWe demonstrated greater passive force and viscoelastic properties at the level of single fibers in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.