ArticleEuropean journal of applied physiology2019
No acute effects of placebo or open-label placebo treatments on strength, voluntary activation, and neuromuscular fatigue.
Article in European journal of applied physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Open-label placebos-a systematic review and meta-analysis of experimental studies with non-clinical samples.Scientific reports · 2023Pooled it
- The influence of integrated healthcare on the nursing effect, negative emotions, and heart failure indicators in acute heart failure patients.American journal of translational research · 2021Article
- Is Open-Label Placebo a New Ergogenic Aid? A Commentary on Existing Studies and Guidelines for Future Research.Sports medicine (Auckland, N.Z.) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRecent evidence suggests that deception may not be necessary for placebos to improve clinical outcomes. We tested the hypothesis that placebo and open-label placebo (OLP) treatments would acutely improve strength and voluntary activation, as well as minimize neuromuscular fatigue, in untrained participants.
methodsTwenty-one males (n = 11) and females (n = 10) visited the laboratory on three occasions (placebo, OLP, control) to receive each treatment in a randomized, counter-balanced manner. Trials involved a pretest, a 15-min intervention, and posttests. For the placebo trial, participants were informed that they would be ingesting a capsule that would improve their performance and make them feel more energetic. For the OLP intervention, participants were told that the capsules would have no effects. In "Experiment #1", knee extensor maximal voluntary contraction (MVC) peak torque and percent voluntary activation were evaluated. In "Experiment #2", participants performed 20 consecutive MVCs while surface electromyographic signals were detected from the vastus lateralis. Subjective assessments of energy and perceived exertion were examined.
resultsThe interventions had no effect on strength or voluntary activation, but energy levels increased following treatments (p = 0.016, η
conclusionPlacebo and OLP treatments had minimal influence on strength, voluntary activation, and fatigue resistance. As these findings differ from recent reports, we speculate that placebos and OLPs are more likely to enhance muscle function in patient populations seeking medical care.
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Registered trials
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