Evidence map›Paper›PMID 31468161›Full record

ArticleEuropean radiology2020

Arterial spin labeling perfusion-weighted imaging aids in prediction of molecular biomarkers and survival in glioblastomas.

Roh-Eul Yoo, Tae Jin Yun, Inpyeong Hwang, Eun Kyoung Hong, Koung Mi Kang, Seung Hong Choi, Chul-Kee Park, Jae-Kyung Won, Ji-Hoon Kim, Chul-Ho Sohn

Abstract read
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In one paragraph

Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 43 citations in OpenAlex.

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  12. Arterial Spin Labeling: Key Concepts and Progress Towards Use as a Clinical Tool.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024
    Review
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  17. Advanced MR Techniques for Preoperative Glioma Characterization: Part 1.Journal of magnetic resonance imaging : JMRI · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Roh-Eul YooInstitute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
Tae Jin YunInstitute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea. radiologyyun@gmail.com.ORCID http://orcid.org/0000-0001-8441-4574
Inpyeong HwangInstitute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
Eun Kyoung HongInstitute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
Koung Mi KangInstitute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
Seung Hong ChoiInstitute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
Chul-Kee ParkDepartment of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea.
Jae-Kyung WonDepartment of Pathology, Seoul National University Hospital, Seoul, Republic of Korea.
Ji-Hoon KimInstitute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
Chul-Ho SohnInstitute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
Seoul National University · KRSeoul National University Hospital · KR

Funding

Seoul National University Hospital 04-2015-0690
6 · The paper itself

Abstract

objectivesPrediction of progression-free survival (PFS) and overall survival (OS) and early identification of molecular biomarkers with prognostic information are clinically important in glioblastoma (GBM) patients. We aimed to explore the utility of arterial spin labeling perfusion-weighted imaging (ASL-PWI) in the prediction of molecular biomarkers and survival in GBM patients.

methodsWe retrospectively analyzed 149 consecutive GBM patients, who had undergone maximal surgical resection or biopsy followed by concurrent chemoradiotherapy and adjuvant chemotherapy using temozolomide between November 2010 and June 2016. On preoperative ASL-PWI, cerebral blood flow (CBF) within contrast-enhancing (CE) and nonenhancing (NE) portions were evaluated both qualitatively (perfusion pattern

resultsnCBF

conclusionsASL-PWI can aid to predict survival and molecular biomarkers including IDH mutation and MGMT promoter methylation statuses in GBM patients. KEY POINTS: • ASL-PWI can aid to predict survival in GBM patients. • ASL-PWI can aid to predict IDH and MGMT promoter methylation statuses in GBM.

Indexed as

AdultAgedAntineoplastic Agents, AlkylatingBiomarkers, TumorBrain NeoplasmsCerebrovascular CirculationChemoradiotherapyChemotherapy, AdjuvantDNA MethylationDNA Modification MethylasesDNA Repair EnzymesFemaleGlioblastomaHumansIsocitrate DehydrogenaseMaleAntineoplastic Agents, AlkylatingBiomarkers, TumorDNA Modification MethylasesDNA Repair EnzymesIsocitrate DehydrogenaseMGMT protein, humanTemozolomideTumor Suppressor ProteinsGlioblastomaIsocitrate dehydrogenaseOverall survivalPerfusion-weighted imagingProgression-free survival

Identifiers

PMID31468161
OpenAlexW2970910661

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.