Evidence map›Paper›PMID 31468150›Full record

ArticleSurgery today2020

Transplantation of a decellularized mitral valve complex in pigs.

Yu Inaba, Hiroshi Yagi, Kohei Kuroda, Jungo Kato, Yujiro Kawai, Mio Kasai, Hiroto Kitahara, Tsutomu Ito, Motohiko Osako, Yuko Kitagawa and 1 more

Abstract read
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Article in Surgery today, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yu InabaDepartment of Cardiovascular Surgery, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.
Hiroshi YagiDepartment of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan. h_yagi@a3.keio.jp.
Kohei KurodaDepartment of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.
Jungo KatoDepartment of Anesthesiology, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.
Yujiro KawaiDepartment of Cardiovascular Surgery, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.
Mio KasaiDepartment of Cardiovascular Surgery, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguroku, Tokyo, 152-8902, Japan.
Hiroto KitaharaDepartment of Cardiovascular Surgery, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.
Tsutomu ItoDepartment of Cardiovascular Surgery, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.
Motohiko OsakoDepartment of Cardiovascular Surgery, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguroku, Tokyo, 152-8902, Japan.
Yuko KitagawaDepartment of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.
Hideyuki ShimizuDepartment of Cardiovascular Surgery, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeConventional mitral valve replacement is associated with the loss of natural continuity of the mitral valve complex. This study evaluated the morphologic/histological characteristics and function of a decellularized mitral valve used as a transplantable graft.

methodsHearts excised from pigs were decellularized by perfusion using detergent. Grafts with the mitral annulus, valve, chordae, and papillary muscle isolated from the decellularized heart were then transplanted into recipient pigs. After transplantation, the function of the graft was analyzed through echocardiography. A histological analysis was performed to evaluate the postoperative features of the decellularized graft.

resultsThe decellularized graft was successfully transplanted in all cases but one. The remaining grafts maintained their morphology and function. They did not exhibit mitral regurgitation or stenosis. Only one animal survived for 3 weeks, and a histological analysis was able to be performed in this case. The transplanted valve was re-covered with endothelial cells. The microvessels in the papillary muscle were recellularized with vascular endothelial cells, and the papillary muscle was completely attached to the papillary muscle of the recipient.

conclusionThe early outcome of decellularized mitral graft transplantation was acceptable. This native organ-derived acellular scaffold is a promising candidate for the replacement of the mitral valve complex.

Indexed as

AnimalsGraft SurvivalHeart Valve Prosthesis ImplantationMitral ValvePerfusionSwineTissue ScaffoldsDecellularizationMitral valveOrgan engineeringTissue engineering

Identifiers

PMID31468150

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.