Evidence map›Paper›PMID 31468138›Full record

ArticlePflugers Archiv : European journal of physiology2019

Fast relaxation and desensitization of angiotensin II contraction in the pulmonary artery via AT1R and Akt-mediated phosphorylation of muscular eNOS.

Hae Jin Kim, Ji Hyun Jang, Yin Hua Zhang, Hae Young Yoo, Sung Joon Kim

Abstract read
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In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Unconventional eNOS in pulmonary artery smooth muscles: why should it be there?Pflugers Archiv : European journal of physiology · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Hae Jin KimDepartment of Physiology, Seoul National University College of Medicine, Seoul, 03080, South Korea.
Ji Hyun JangDepartment of Physiology, Seoul National University College of Medicine, Seoul, 03080, South Korea.
Yin Hua ZhangDepartment of Physiology, Seoul National University College of Medicine, Seoul, 03080, South Korea.
Hae Young YooChung-Ang University Red Cross College of Nursing, Seoul, 100-031, South Korea.
Sung Joon KimDepartment of Physiology, Seoul National University College of Medicine, Seoul, 03080, South Korea. physiolksj@gmail.com.ORCID 0000-0002-0289-121X
Seoul National University · KRChung-Ang University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiotensin II (AngII) triggers a transient contraction of pulmonary arteries (PAs) followed by protracted desensitization. Based on the unconventional eNOS expression in PA smooth muscle cells (PASMCs), we hypothesized that activation of smooth muscle eNOS by AngII might be responsible for fast relaxation and tachyphylaxis. Using dual-wire myograph, mechanically endothelium-denuded rat PA [E(-)PA] showed AngII concentration-dependent transient contractions (ΔT

Indexed as

VasoconstrictionVasodilationAngiotensin IIAngiotensin II Type 1 Receptor BlockersAnimalsCarbazolesCells, CulturedEnzyme InhibitorsHumansImidazolesLosartanMaleMuscle, Smooth, VascularMyocytes, Smooth MuscleNG-Nitroarginine Methyl EsterNitric Oxide Synthase Type III1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one7-Ala-angiotensin (1-7)Angiotensin IIAngiotensin II Type 1 Receptor BlockersCarbazolesEnzyme InhibitorsImidazolesKT 5823LosartanNG-Nitroarginine Methyl EsterNitric Oxide Synthase Type IIIOxadiazolesPD 123319Peptide FragmentsProto-Oncogene MasProto-Oncogene Proteins c-aktPyridinesQuinoxalinesReceptor, Angiotensin, Type 1Angiotensin IIAT1ReNOSPulmonary arterySmooth muscle

Identifiers

PMID31468138
OpenAlexW2970655147

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.