ArticleBioMed research international2019
Tissue Composition and Biomechanical Property Changes in the Vaginal Wall of Ovariectomized Young Rats.
Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Aging of Pelvic Floor in Animal Models: A Sistematic Review of Literature on the Role of the Extracellular Matrix in the Development of Pelvic Floor Prolapse.Frontiers in medicine · 2022Pooled it
- Animal models for pelvic organ prolapse: systematic review.International urogynecology journal · 2021Pooled it
- Terpene-enhanced olaminogel for superior vaginal permeation: robust assessment through in vitro, microbiological, ex vivo, and in vivo evaluations.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Assessing Vaginal Wall Elasticity via Shear-Wave Elastography Using a Transrectal Linear Array High-Frequency Probe in Premenopausal versus Postmenopausal Women: A Cross-Sectional Feasibility Study.International journal of women's health · 2026Article
- Development of a Vaginal Extracellular Matrix Hydrogel for Combating Genitourinary Syndrome of Menopause.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Vaginal biomechanical function in premenopausal and postmenopausal women with and without pelvic organ prolapse.Scientific reports · 2025Article
- Developing a procedure mimicking transvaginal mesh implantation in women in a modified POP rat model.Frontiers in medicine · 2025Article
- Mechanical Stress-Oxidative Stress Axis: Biological Basis in the Vaginal Wall and Pelvic Floor Muscles of Rats with Simulated Birth Injury.International urogynecology journal · 2024Article
- Functional outcome of the anterior vaginal wall in a pelvic surgery injury rat model after treatment with stem cell-derived progenitors of smooth muscle cells.Stem cell research & therapy · 2024Article
- Functional outcome of the anterior vaginal wall in a pelvic surgery injury rat model after treatment with stem cell-derived progenitors of smooth muscle cells.Research square · 2024Article
- Vaginal Fibroblast Behavior as a Function of Stiffness Changes in a Polyisocyanide Hydrogel for Prolapse Repair.ACS applied bio materials · 2023Article
- Cellular and extracellular vaginal changes following murine ovarian removal.Physiological reports · 2023Article
- Current practice in animal models for pelvic floor dysfunction.International urogynecology journal · 2023Review
- scRNA-seq reveals aging-related immune cell types and regulators in vaginal wall from elderly women with pelvic organ prolapse.Frontiers in immunology · 2023Article
- Human umbilical cord mesenchymal stem cells reconstruct the vaginal wall of ovariectomized Sprague-Dawley rats: implications for pelvic floor reconstruction.Cell and tissue research · 2021Article
- Mesenchymal stem cell transplantation for vaginal repair in an ovariectomized rhesus macaque model.Stem cell research & therapy · 2021Article
- Animal Models and Alternatives in Vaginal Research: a Comparative Review.Reproductive sciences (Thousand Oaks, Calif.) · 2021Review
- Organization of the fibrous connective tissue of the fallopian tubes in fertile and climacteric periods: a scanning electron microscopic and stereologic study.International journal of clinical and experimental pathology · 2021Article
- Ultra-deformable liposomes containing terpenes (terpesomes) loaded fenticonazole nitrate for treatment of vaginal candidiasis: Box-Behnken design optimization, comparativeDrug delivery · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ideal animal models are needed to reflect the changes in the biochemical and biomechanical properties of the vagina that occur in pelvic organ prolapse (POP). In this study, we aimed to demonstrate the short and long-term effect of menopause on the biochemical and biomechanical properties of rat anterior vaginas. Here, Sprague-Dawley rats were bilaterally ovariectomized to induce menopause. Rats without ovariectomy served as the normal control group (n=12). The histology changes and the expression of collagen I, III, and a-SMA were assessed to indicate the biochemical changes in the vagina 2 weeks, 4 weeks, and 16 weeks after ovariectomy (n=6 for 2 and 4 weeks, n=12 for 16 weeks). Uniaxial biomechanical testing was conducted in the control group and ovariectomized rats 16 weeks after ovariectomy. Compared with the control group, the ovariectomy group showed a significant increase in the expression of collagen I 2 weeks after ovariectomy, while collagen III showed a declining trend. Two weeks after ovariectomy, the smooth muscle bundles began to become disorganized, and the fraction of smooth muscle in the nonvascular muscularis of the proximal vagina was significantly decreased (P<0.001). However, there was no difference in the expression of a-SMA in the distal vagina. Compared with the control group, the ovariectomy group had stiffer vaginas with a declining trend in the ultimate load 16 weeks after ovariectomy. In conclusion, surgically induced menopause had a significant short- and long-term impact on tissue composition and biomechanical properties of the rat vagina, which may lead to increased susceptibility to POP development.
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