ArticleBioMed research international2019
Bta-miR-124a Affects Lipid Metabolism by Regulating
Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- miRNA in Diagnosis and Therapeutics of Tuberculosis: Importance in Latent and Brain Associated Pathologies.Current pharmaceutical design · 2026Review
- Bioinformatics analysis reveals the association of bile acid metabolism-related genes with sepsis.PloS one · 2026Article
- Host miRNAs regulate Escherichia coli O157 mucosal colonization through host-mucosa-attached microbiota interactions in calves.Microbiome · 2025Article
- Identification and analysis of immune cell-related genes in cutaneous squamous cell carcinoma and drug network prediction.Archives of dermatological research · 2024Article
- Synergistic Responses of Tibetan Sheep Rumen Microbiota, Metabolites, and the Host to the Plateau Environment.International journal of molecular sciences · 2023Article
- MicroRNAs in Ruminants and Their Potential Role in Nutrition and Physiology.Veterinary sciences · 2023Review
- Bta-miR-33a affects gene expression and lipid levels in Chinese Holstein mammary epithelial cells.Archives animal breeding · 2022Article
- The Role of microRNAs in the Mammary Gland Development, Health, and Function of Cattle, Goats, and Sheep.Non-coding RNA · 2021Review
- Progress on the Regulation of Ruminant Milk Fat by Noncoding RNAs and ceRNAs.Frontiers in genetics · 2021Review
- Progress in epigenetic regulation of milk synthesis, with particular emphasis on mRNA regulation and DNA methylation.Cell cycle (Georgetown, Tex.)Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to our previous studies, bta-miR-124a was differentially expressed in breast tissue between high-fat and low-fat dairy cows. However, the function of bta-miR-124a in lipid metabolism of dairy cows and the identification of its target genes have not been reported. Therefore, this study will identify the target gene of bta-miR-124a and explore its role in the regulation of milk lipid metabolism. First, preliminary bioinformatics prediction of bta-miR-124a candidate target genes was performed, and quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze relative expression changes of bta-miR-124a and its candidate target genes and the expression level of the downstream gene of the target gene in the lipid metabolism signaling pathway in dairy mammary epithelial cell lines (Mac-T), using the dual luciferase reporter system for the identification of the targeting relationship between bta-miR-124a and the candidate target gene. Then, the effect of transfection of bta-miR-124a mimics and inhibitors on triglyceride (TG) and free fatty acid (FFA) levels was analyzed. The results indicate that bta-miR-124a directly interacts with the 3'-untranslated region of peroxisomal trans-2-enoyl-CoA reductase (
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