Evidence map›Paper›PMID 31467866›Full record

ArticleInternational journal of genomics2019

Accumulation of Circulating Cell-Free CpG-Enriched Ribosomal DNA Fragments on the Background of High Endonuclease Activity of Blood Plasma in Schizophrenic Patients.

E S Ershova, E M Jestkova, A V Martynov, G V Shmarina, P E Umriukhin, L V Bravve, N V Zakharova, G P Kostyuk, D V Saveliev, M D Orlova and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

E S ErshovaResearch Centre for Medical Genetics (RCMG), Moscow 115478, Russia.
E M JestkovaPsychiatric Hospital No. 4 of Moscow City Health Department, Moscow 115447, Russia.
A V MartynovResearch Centre for Medical Genetics (RCMG), Moscow 115478, Russia.
G V ShmarinaResearch Centre for Medical Genetics (RCMG), Moscow 115478, Russia.ORCID https://orcid.org/0000-0003-4851-8987
P E UmriukhinI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.ORCID https://orcid.org/0000-0001-8628-7353
L V BravveN.A. Alexeev Clinical Psychiatric Hospital No. 1 of Moscow Healthcare Department, Moscow 115447, Russia.
N V ZakharovaN.A. Alexeev Clinical Psychiatric Hospital No. 1 of Moscow Healthcare Department, Moscow 115447, Russia.
G P KostyukN.A. Alexeev Clinical Psychiatric Hospital No. 1 of Moscow Healthcare Department, Moscow 115447, Russia.
D V SavelievN.A. Alexeev Clinical Psychiatric Hospital No. 1 of Moscow Healthcare Department, Moscow 115447, Russia.
M D OrlovaResearch Centre for Medical Genetics (RCMG), Moscow 115478, Russia.
M BogushRowan University Biological Sciences Department, Science Hall, Glassboro, New Jersey, USA.
S I KutsevResearch Centre for Medical Genetics (RCMG), Moscow 115478, Russia.
N N VeikoResearch Centre for Medical Genetics (RCMG), Moscow 115478, Russia.
S V KostyukResearch Centre for Medical Genetics (RCMG), Moscow 115478, Russia.ORCID https://orcid.org/0000-0003-2116-1244
Moscow Research and Clinical Center for Neuropsychiatry · RUResearch Centre for Medical Genetics · RUSechenov University · RURowan University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSchizophrenia (SZ) increases the level of cell death, leading to an increase in the concentration of circulating cell-free DNA (cfDNA). Ribosomal DNA (rDNA) contains many unmethylated CpG motifs that stimulate TLR9-MyD88-NF-

resultsIn the subjects from the SZ group, the mean cfDNA plasma concentration was twofold higher and NA of the plasma was fourfold higher than those in the healthy controls. rDNA CN in the blood leukocyte genome and in the cfDNA samples in the SZ group was significantly higher than that in the HC group. cf-rDNA concentration was threefold higher in the SZ group.

conclusionDespite the abnormally high endonuclease activity in the blood plasma of SZ patients, the circulating cfDNA concentration is increased. Fragments of cf-rDNA accumulate in the blood plasma of SZ patients. Potentially, SZ patients' cfDNA should be a strong stimulating factor for the TLR9-MyD88-NF-

Identifiers

PMID31467866
PMCPMC6701307
OpenAlexW2965429189

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.