Evidence map›Paper›PMID 31467776›Full record

ArticleBiomedical optics express2019

Active Er-laser drug delivery using drug-impregnated gel for treatment of nail diseases.

Andrey V Belikov, Anastasia D Tavalinskaya, Sergey N Smirnov, Andrey N Sergeev

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Fractional COLasers in surgery and medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Andrey V BelikovFaculty of Laser Photonics and Optoelectronics, ITMO University, 49 Kronverksky Pr, St. Petersburg, 197101, Russia.
Anastasia D TavalinskayaFaculty of Laser Photonics and Optoelectronics, ITMO University, 49 Kronverksky Pr, St. Petersburg, 197101, Russia.
Sergey N SmirnovFaculty of Laser Photonics and Optoelectronics, ITMO University, 49 Kronverksky Pr, St. Petersburg, 197101, Russia.
Andrey N SergeevFaculty of Laser Photonics and Optoelectronics, ITMO University, 49 Kronverksky Pr, St. Petersburg, 197101, Russia.
ITMO University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Active Er-laser drug delivery under the nail plate using a drug-impregnated gel containing liquid methylene blue clusters is demonstrated for the first time. The effect of the agar-agar concentration in the gel and the gel plate thickness on the number of Er:YLF-laser pulses required for formation of a through microhole in the gel and in the nail plate with subsequent active drug delivery is discussed. The influence of the laser pulse energy, the gel plate thickness, and the external pressure applied to the gel on the rate of delivery of methylene blue under the nail plate through a single microhole in it is investigated. It is shown that with a laser pulse energy of 4.0 ± 0.1 mJ, the delivery rate can reach 0.024 ± 0.004 mg/pulse.

Identifiers

PMID31467776
PMCPMC6706032
OpenAlexW2949592456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.