Evidence map›Paper›PMID 31467687›Full record

ArticleMolecular systems design & engineering2018

Evaluation of affibody charge modification identified by synthetic consensus design in molecular PET imaging of epidermal growth factor receptor.

Brett A Case, Max A Kruziki, Lawrence A Stern, Benjamin J Hackel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular systems design & engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. PET and SPECT Imaging of the EGFR Family (RTK Class I) in Oncology.International journal of molecular sciences · 2021
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brett A CaseDepartment of Chemical Engineering and Materials Science, University of Minnesota - Twin Cities, Minneapolis, MN 55455.
Max A KruzikiDepartment of Chemical Engineering and Materials Science, University of Minnesota - Twin Cities, Minneapolis, MN 55455.
Lawrence A SternDepartment of Chemical Engineering and Materials Science, University of Minnesota - Twin Cities, Minneapolis, MN 55455.
Benjamin J HackelDepartment of Chemical Engineering and Materials Science, University of Minnesota - Twin Cities, Minneapolis, MN 55455.

Funding

Enhanced molecular imaging agents via designed ligand chargeR21EB021511 · NIBIB · UNIVERSITY OF MINNESOTA · PI HACKEL, BENJAMIN · 2016 to 2017
$408k
NIBIB NIH HHS R21 EB021511
6 · The paper itself

Abstract

Tumor overexpression of epidermal growth factor receptor (EGFR) correlates to therapeutic response in select patient populations. Thus, molecular positron emission tomography (PET) imaging of EGFR could stratify responders versus non-responders. We previously demonstrated effectiveness of a "synthetic consensus" design principle to identify six neutralizing mutations within a 58-amino acid EGFR-targeted affibody domain. Herein, we extend the approach to identify additional neutralized variants that vary net charge from -2 to either -4 or +4 while retaining high affinity (1.6 ± 1.2 nM and 2.5 ± 0.7 nM), specific binding to EGFR, secondary structure, and stability (T

Identifiers

PMID31467687
PMCPMC6715147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.