Evidence map›Paper›PMID 31467629›Full record

ArticleOxidative medicine and cellular longevity2019

Gamma Radiation-Induced Disruption of Cellular Junctions in HUVECs Is Mediated through Affecting MAPK/NF-

H Wang, R Chandra Segaran, L Y Chan, Aref A M Aladresi, A Chinnathambi, S A Alharbi, G Sethi, F R Tang

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Zonula Occludens Proteins Signaling in Inflammation and Tumorigenesis.International journal of biological sciences · 2023
    Review
  9. Review
  10. Review
  11. Role of p53 in Regulating Radiation Responses.Life (Basel, Switzerland) · 2022
    Review
  12. Article
  13. Review
  14. Article
  15. Mechanisms of radiation-induced endothelium damage: Emerging models and technologies.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2021
    Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

H WangRadiobiology Research Laboratory, Singapore Nuclear Research and Safety Initiative, National University of Singapore, Singapore 138602.
R Chandra SegaranRadiobiology Research Laboratory, Singapore Nuclear Research and Safety Initiative, National University of Singapore, Singapore 138602.
L Y ChanRadiobiology Research Laboratory, Singapore Nuclear Research and Safety Initiative, National University of Singapore, Singapore 138602.
Aref A M AladresiDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
A ChinnathambiDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
S A AlharbiDepartment of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
G SethiDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600.ORCID https://orcid.org/0000-0002-8677-8475
F R TangRadiobiology Research Laboratory, Singapore Nuclear Research and Safety Initiative, National University of Singapore, Singapore 138602.ORCID https://orcid.org/0000-0003-2462-1787
National University of Singapore · SGKing Saud University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ionizing radiation-induced cardiovascular diseases (CVDs) have been well documented. However, the mechanisms of CVD genesis are still not fully understood. In this study, human umbilical vein endothelial cells (HUVECs) were exposed to gamma irradiation at different doses ranging from 0.2 Gy to 5 Gy. Cell viability, migration ability, permeability, oxidative and nitrosative stresses, inflammation, and nuclear factor kappa-light-chain-enhancer of activated B cell (NF-

Indexed as

Gamma RaysHumansHuman Umbilical Vein Endothelial CellsMitogen-Activated Protein KinasesNF-kappa BMitogen-Activated Protein KinasesNF-kappa B

Identifiers

PMID31467629
PMCPMC6701340
OpenAlexW2966611492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.