Evidence map›Paper›PMID 31467618›Full record

SynthesisDisease markers2019

Lei Wu, Wenwen Shang, Hong Zhao, Guodong Rong, Yan Zhang, Ting Xu, Jiexin Zhang, Peijun Huang, Fang Wang

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Disease markers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Early diagonosis of ovarian cancer: serum HE4, CA125 and ROMA model.American journal of translational research · 2021
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Lei WuDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, China.
Wenwen ShangDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, China.
Hong ZhaoDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, China.
Guodong RongDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, China.
Yan ZhangDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, China.
Ting XuDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, China.
Jiexin ZhangDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, China.
Peijun HuangDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, China.
Fang WangDepartment of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, 210029 Nanjing, China.ORCID https://orcid.org/0000-0002-6631-2045
Jiangsu Province Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current screening tests for the diagnosis of ovarian cancer (OC) face enduring challenges. However, microRNAs (miRNAs) are stable in the circulation and may be promising molecular biomarkers for OC prediction. Circulating miRNA expression profiles in OC were analyzed using sequencing data from the Gene Expression Omnibus database. Differentially expressed miRNAs were generated from GSE94533, of which some were selected as candidate miRNAs based on an electronic search of the literature and comprehensive evaluation. A meta-analysis was preformed to integrate an evaluation index for these miRNAs in diagnosing OC patients. An independent validation set (GSE106817) was also conducted to further confirm the roles of these miRNAs. We identified four

Indexed as

Biomarkers, TumorCell-Free Nucleic AcidsFemaleHumansMicroRNAsOvarian NeoplasmsBiomarkers, TumorCell-Free Nucleic AcidsMicroRNAs

Identifiers

PMID31467618
PMCPMC6701281
OpenAlexW2966011408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.